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Evaluation of Crocin Effect on Contrast-Induced Nephropathy Following Coronary Angiography or Angioplasty: A Randomized Controlled Trial

Contrast-induced nephropathy (CIN) is the third cause of hospital-acquired acute kidney injury. The CIN prophylactic strategies adopted to date, although not highly efficient, are mostly based on antioxidant activity and hydration therapy. This study was designed and conducted to evaluate crocin’s e...

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Autores principales: Shojaei, Lida, Esfandiary, Shima, Rouzbahani, Mohammad, Heydarpour, Fatemeh, Bahremand, Mostafa, Heidary Moghadam, Reza, Mahmoudi, Ghazal, Korani, Farzaneh, Raissi, Farshid, Shahbazi, Foroud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Brieflands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420216/
https://www.ncbi.nlm.nih.gov/pubmed/36060925
http://dx.doi.org/10.5812/ijpr-126920
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author Shojaei, Lida
Esfandiary, Shima
Rouzbahani, Mohammad
Heydarpour, Fatemeh
Bahremand, Mostafa
Heidary Moghadam, Reza
Mahmoudi, Ghazal
Korani, Farzaneh
Raissi, Farshid
Shahbazi, Foroud
author_facet Shojaei, Lida
Esfandiary, Shima
Rouzbahani, Mohammad
Heydarpour, Fatemeh
Bahremand, Mostafa
Heidary Moghadam, Reza
Mahmoudi, Ghazal
Korani, Farzaneh
Raissi, Farshid
Shahbazi, Foroud
author_sort Shojaei, Lida
collection PubMed
description Contrast-induced nephropathy (CIN) is the third cause of hospital-acquired acute kidney injury. The CIN prophylactic strategies adopted to date, although not highly efficient, are mostly based on antioxidant activity and hydration therapy. This study was designed and conducted to evaluate crocin’s efficacy in the prevention of CIN in chronic kidney disease (CKD) patients undergoing coronary angiography/angioplasty. In this randomized clinical trial, a total of 110 eligible CKD stage 3 patients requiring contrast agent administration for coronary angiography/angioplasty were enrolled and randomly assigned to either crocin (n = 57) or control (n = 53) group. The patients in both groups received standard hydration therapy; nevertheless, in the crocin group, the patients were also orally administered three consecutive oral doses of 30 mg crocin tablets 1 day before up to 1 day after contrast media (CM) exposure. The primary endpoint was CIN incidence defined as an increase in serum creatinine (SrCr) level by ≥ 0.3 mg/dL or any change in urinary neutrophil gelatinase-associated lipocalin (NGAL) from the baseline within 48 hours of CM exposure. During 4 months, 130 patients were recruited. The mean age of the patients was 65.62 ± 9.05 years, and the majority of them were male (64.54%). The SrCr in the crocin group did not significantly increase within 48 hours of angiography/angioplasty. The changes in the urinary NGAL level were not significant in both groups. The CIN incidence was significantly lower in the crocin group than in the control group (1.75% and 13.2%; P = 0.028). Crocin administration plays an important nephron-protective role in the prevention of CIN.
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spelling pubmed-94202162022-09-02 Evaluation of Crocin Effect on Contrast-Induced Nephropathy Following Coronary Angiography or Angioplasty: A Randomized Controlled Trial Shojaei, Lida Esfandiary, Shima Rouzbahani, Mohammad Heydarpour, Fatemeh Bahremand, Mostafa Heidary Moghadam, Reza Mahmoudi, Ghazal Korani, Farzaneh Raissi, Farshid Shahbazi, Foroud Iran J Pharm Res Research Article Contrast-induced nephropathy (CIN) is the third cause of hospital-acquired acute kidney injury. The CIN prophylactic strategies adopted to date, although not highly efficient, are mostly based on antioxidant activity and hydration therapy. This study was designed and conducted to evaluate crocin’s efficacy in the prevention of CIN in chronic kidney disease (CKD) patients undergoing coronary angiography/angioplasty. In this randomized clinical trial, a total of 110 eligible CKD stage 3 patients requiring contrast agent administration for coronary angiography/angioplasty were enrolled and randomly assigned to either crocin (n = 57) or control (n = 53) group. The patients in both groups received standard hydration therapy; nevertheless, in the crocin group, the patients were also orally administered three consecutive oral doses of 30 mg crocin tablets 1 day before up to 1 day after contrast media (CM) exposure. The primary endpoint was CIN incidence defined as an increase in serum creatinine (SrCr) level by ≥ 0.3 mg/dL or any change in urinary neutrophil gelatinase-associated lipocalin (NGAL) from the baseline within 48 hours of CM exposure. During 4 months, 130 patients were recruited. The mean age of the patients was 65.62 ± 9.05 years, and the majority of them were male (64.54%). The SrCr in the crocin group did not significantly increase within 48 hours of angiography/angioplasty. The changes in the urinary NGAL level were not significant in both groups. The CIN incidence was significantly lower in the crocin group than in the control group (1.75% and 13.2%; P = 0.028). Crocin administration plays an important nephron-protective role in the prevention of CIN. Brieflands 2022-06-14 /pmc/articles/PMC9420216/ /pubmed/36060925 http://dx.doi.org/10.5812/ijpr-126920 Text en Copyright © 2022, Author(s) https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Shojaei, Lida
Esfandiary, Shima
Rouzbahani, Mohammad
Heydarpour, Fatemeh
Bahremand, Mostafa
Heidary Moghadam, Reza
Mahmoudi, Ghazal
Korani, Farzaneh
Raissi, Farshid
Shahbazi, Foroud
Evaluation of Crocin Effect on Contrast-Induced Nephropathy Following Coronary Angiography or Angioplasty: A Randomized Controlled Trial
title Evaluation of Crocin Effect on Contrast-Induced Nephropathy Following Coronary Angiography or Angioplasty: A Randomized Controlled Trial
title_full Evaluation of Crocin Effect on Contrast-Induced Nephropathy Following Coronary Angiography or Angioplasty: A Randomized Controlled Trial
title_fullStr Evaluation of Crocin Effect on Contrast-Induced Nephropathy Following Coronary Angiography or Angioplasty: A Randomized Controlled Trial
title_full_unstemmed Evaluation of Crocin Effect on Contrast-Induced Nephropathy Following Coronary Angiography or Angioplasty: A Randomized Controlled Trial
title_short Evaluation of Crocin Effect on Contrast-Induced Nephropathy Following Coronary Angiography or Angioplasty: A Randomized Controlled Trial
title_sort evaluation of crocin effect on contrast-induced nephropathy following coronary angiography or angioplasty: a randomized controlled trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420216/
https://www.ncbi.nlm.nih.gov/pubmed/36060925
http://dx.doi.org/10.5812/ijpr-126920
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