Screening for neurodegeneration in Langerhans cell histiocytosis with neurofilament light in plasma

Patients with Langerhans cell histiocytosis (LCH) may develop progressive neurodegeneration in the central nervous system (ND‐CNS‐LCH). Neurofilament light protein (NFL) in cerebrospinal fluid (CSF) is a promising biomarker to detect and monitor ND‐CNS‐LCH. We compared paired samples of NFL in plasm...

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Autores principales: Sveijer, Malin, von Bahr Greenwood, Tatiana, Jädersten, Martin, Kvedaraite, Egle, Zetterberg, Henrik, Blennow, Kaj, Lourda, Magda, Gavhed, Désirée, Henter, Jan‐Inge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Haematological Malignancy–Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420236/
https://www.ncbi.nlm.nih.gov/pubmed/35582775
http://dx.doi.org/10.1111/bjh.18247
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author Sveijer, Malin
von Bahr Greenwood, Tatiana
Jädersten, Martin
Kvedaraite, Egle
Zetterberg, Henrik
Blennow, Kaj
Lourda, Magda
Gavhed, Désirée
Henter, Jan‐Inge
author_facet Sveijer, Malin
von Bahr Greenwood, Tatiana
Jädersten, Martin
Kvedaraite, Egle
Zetterberg, Henrik
Blennow, Kaj
Lourda, Magda
Gavhed, Désirée
Henter, Jan‐Inge
author_sort Sveijer, Malin
collection PubMed
description Patients with Langerhans cell histiocytosis (LCH) may develop progressive neurodegeneration in the central nervous system (ND‐CNS‐LCH). Neurofilament light protein (NFL) in cerebrospinal fluid (CSF) is a promising biomarker to detect and monitor ND‐CNS‐LCH. We compared paired samples of NFL in plasma (p‐NFL) and CSF in 10 patients (19 samples). Nine samples had abnormal CSF‐NFL (defined as ≥380 ng/l) with corresponding p‐NFL ≥ 2 ng/l. Ten samples had CSF‐NFL < 380 ng/l; eight (80%) with p‐NFL < 2 ng/l (p < 0.001; Fisher's exact test). Thus, our results suggest that p‐NFL may be used to screen for ND‐CNS‐LCH. Further studies are encouraged, including the role of p‐NFL for monitoring of ND‐CNS‐LCH.
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spelling pubmed-94202362022-10-14 Screening for neurodegeneration in Langerhans cell histiocytosis with neurofilament light in plasma Sveijer, Malin von Bahr Greenwood, Tatiana Jädersten, Martin Kvedaraite, Egle Zetterberg, Henrik Blennow, Kaj Lourda, Magda Gavhed, Désirée Henter, Jan‐Inge Br J Haematol Haematological Malignancy–Clinical Patients with Langerhans cell histiocytosis (LCH) may develop progressive neurodegeneration in the central nervous system (ND‐CNS‐LCH). Neurofilament light protein (NFL) in cerebrospinal fluid (CSF) is a promising biomarker to detect and monitor ND‐CNS‐LCH. We compared paired samples of NFL in plasma (p‐NFL) and CSF in 10 patients (19 samples). Nine samples had abnormal CSF‐NFL (defined as ≥380 ng/l) with corresponding p‐NFL ≥ 2 ng/l. Ten samples had CSF‐NFL < 380 ng/l; eight (80%) with p‐NFL < 2 ng/l (p < 0.001; Fisher's exact test). Thus, our results suggest that p‐NFL may be used to screen for ND‐CNS‐LCH. Further studies are encouraged, including the role of p‐NFL for monitoring of ND‐CNS‐LCH. John Wiley and Sons Inc. 2022-05-17 2022-08 /pmc/articles/PMC9420236/ /pubmed/35582775 http://dx.doi.org/10.1111/bjh.18247 Text en © 2022 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Haematological Malignancy–Clinical
Sveijer, Malin
von Bahr Greenwood, Tatiana
Jädersten, Martin
Kvedaraite, Egle
Zetterberg, Henrik
Blennow, Kaj
Lourda, Magda
Gavhed, Désirée
Henter, Jan‐Inge
Screening for neurodegeneration in Langerhans cell histiocytosis with neurofilament light in plasma
title Screening for neurodegeneration in Langerhans cell histiocytosis with neurofilament light in plasma
title_full Screening for neurodegeneration in Langerhans cell histiocytosis with neurofilament light in plasma
title_fullStr Screening for neurodegeneration in Langerhans cell histiocytosis with neurofilament light in plasma
title_full_unstemmed Screening for neurodegeneration in Langerhans cell histiocytosis with neurofilament light in plasma
title_short Screening for neurodegeneration in Langerhans cell histiocytosis with neurofilament light in plasma
title_sort screening for neurodegeneration in langerhans cell histiocytosis with neurofilament light in plasma
topic Haematological Malignancy–Clinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420236/
https://www.ncbi.nlm.nih.gov/pubmed/35582775
http://dx.doi.org/10.1111/bjh.18247
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