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Hyperuricemia Increases the Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis

Association between hyperuricemia (HUA) and atrial fibrillation (AF) remains unclear. We reviewed clinical evidence and aimed to determine whether hyperuricemia leads to a high risk of atrial fibrillation. Most studies were identified through databases online. Keywords used in literature search were...

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Autores principales: Gao, Zheng, Shi, Hekai, Xu, Wei, Guan, Zhengzhao, Su, Xiuxiu, Guo, Nuojin, Ma, Huijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420608/
https://www.ncbi.nlm.nih.gov/pubmed/36046801
http://dx.doi.org/10.1155/2022/8172639
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author Gao, Zheng
Shi, Hekai
Xu, Wei
Guan, Zhengzhao
Su, Xiuxiu
Guo, Nuojin
Ma, Huijie
author_facet Gao, Zheng
Shi, Hekai
Xu, Wei
Guan, Zhengzhao
Su, Xiuxiu
Guo, Nuojin
Ma, Huijie
author_sort Gao, Zheng
collection PubMed
description Association between hyperuricemia (HUA) and atrial fibrillation (AF) remains unclear. We reviewed clinical evidence and aimed to determine whether hyperuricemia leads to a high risk of atrial fibrillation. Most studies were identified through databases online. Keywords used in literature search were hyperuricemia, atrial fibrillation, metabolic disorder, endocrine disorder, or uric acid. Three studies were provided by the authors. Literature search was performed without any data or language restriction. Observational studies, including cohort studies and cross-sectional studies, were used. Study type should be clearly defined. Cross-sectional studies should clearly introduce the sources of epidemiological data. Studies were excluded if with too many complications unrelated to AF enrolled. Data were independently extracted by three individuals. Data synthesis was conducted by R version 4.1.2. Prevalence of atrial fibrillation was the main outcome. Results of meta-analysis were presented as risk ratio (RR) for different prevalence of AF between individuals with and without HUA. All data included were obtained after follow-up work is completed. Data from 608,810 participants showed that patients with hyperuricemia were easier to suffer from atrial fibrillation (RR, 2.42; 95% CI, 1.24–3.03). And the meta-regressions suggested growth of linear proportion between the ratio of current drinkers and hyperuricemia (QM = 41.0069, P < 0.001). Subgroup analyses demonstrated consistent results in different countries. And design of the observational studies brought heterogeneity, but no uncertainties. Patients with hyperuricemia were easier to suffer from atrial fibrillation. Treatment of hyperuricemia or gout may bring potential benefits for AF patients.
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spelling pubmed-94206082022-08-30 Hyperuricemia Increases the Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis Gao, Zheng Shi, Hekai Xu, Wei Guan, Zhengzhao Su, Xiuxiu Guo, Nuojin Ma, Huijie Int J Endocrinol Review Article Association between hyperuricemia (HUA) and atrial fibrillation (AF) remains unclear. We reviewed clinical evidence and aimed to determine whether hyperuricemia leads to a high risk of atrial fibrillation. Most studies were identified through databases online. Keywords used in literature search were hyperuricemia, atrial fibrillation, metabolic disorder, endocrine disorder, or uric acid. Three studies were provided by the authors. Literature search was performed without any data or language restriction. Observational studies, including cohort studies and cross-sectional studies, were used. Study type should be clearly defined. Cross-sectional studies should clearly introduce the sources of epidemiological data. Studies were excluded if with too many complications unrelated to AF enrolled. Data were independently extracted by three individuals. Data synthesis was conducted by R version 4.1.2. Prevalence of atrial fibrillation was the main outcome. Results of meta-analysis were presented as risk ratio (RR) for different prevalence of AF between individuals with and without HUA. All data included were obtained after follow-up work is completed. Data from 608,810 participants showed that patients with hyperuricemia were easier to suffer from atrial fibrillation (RR, 2.42; 95% CI, 1.24–3.03). And the meta-regressions suggested growth of linear proportion between the ratio of current drinkers and hyperuricemia (QM = 41.0069, P < 0.001). Subgroup analyses demonstrated consistent results in different countries. And design of the observational studies brought heterogeneity, but no uncertainties. Patients with hyperuricemia were easier to suffer from atrial fibrillation. Treatment of hyperuricemia or gout may bring potential benefits for AF patients. Hindawi 2022-08-21 /pmc/articles/PMC9420608/ /pubmed/36046801 http://dx.doi.org/10.1155/2022/8172639 Text en Copyright © 2022 Zheng Gao et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gao, Zheng
Shi, Hekai
Xu, Wei
Guan, Zhengzhao
Su, Xiuxiu
Guo, Nuojin
Ma, Huijie
Hyperuricemia Increases the Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis
title Hyperuricemia Increases the Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis
title_full Hyperuricemia Increases the Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis
title_fullStr Hyperuricemia Increases the Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis
title_full_unstemmed Hyperuricemia Increases the Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis
title_short Hyperuricemia Increases the Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis
title_sort hyperuricemia increases the risk of atrial fibrillation: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420608/
https://www.ncbi.nlm.nih.gov/pubmed/36046801
http://dx.doi.org/10.1155/2022/8172639
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