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Vancomycin as an Antibacterial Agent Capped with Silver Nanoparticles: An Experimental Potential Analysis

For the treatment of various infections, a variety of antimicrobial drugs are formulated. Nevertheless, many bacterial infections now exhibit antibiotic resistance due to the widespread utilization antibiotics. Methicillin-resistant among the most dangerous multidrug-resistant bacteria is Staphyloco...

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Autores principales: Patwekar, Mohsina, Patwekar, Faheem, Alghamdi, Saad, Kamal, Mehnaz, Allahyani, Mamdouh, Almehmadi, Mazen, Kabrah, Ahmed, Dablool, Anas S., Alsaiari, Ahad Amer, Jawaid, Talha, Medikeri, Anuradha, Samuel, Krupa, Islam, Fahadul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420617/
https://www.ncbi.nlm.nih.gov/pubmed/36046462
http://dx.doi.org/10.1155/2022/3682757
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author Patwekar, Mohsina
Patwekar, Faheem
Alghamdi, Saad
Kamal, Mehnaz
Allahyani, Mamdouh
Almehmadi, Mazen
Kabrah, Ahmed
Dablool, Anas S.
Alsaiari, Ahad Amer
Jawaid, Talha
Medikeri, Anuradha
Samuel, Krupa
Islam, Fahadul
author_facet Patwekar, Mohsina
Patwekar, Faheem
Alghamdi, Saad
Kamal, Mehnaz
Allahyani, Mamdouh
Almehmadi, Mazen
Kabrah, Ahmed
Dablool, Anas S.
Alsaiari, Ahad Amer
Jawaid, Talha
Medikeri, Anuradha
Samuel, Krupa
Islam, Fahadul
author_sort Patwekar, Mohsina
collection PubMed
description For the treatment of various infections, a variety of antimicrobial drugs are formulated. Nevertheless, many bacterial infections now exhibit antibiotic resistance due to the widespread utilization antibiotics. Methicillin-resistant among the most dangerous multidrug-resistant bacteria is Staphylococcus aureus (MRSA). Vancomycin became a viable therapy option due to MRSA resistance to methicillin medicines. One of the well-informed antibacterial compounds with wideband antibacterial activity is silver nanoparticles (AgNPs). AgNPs are thus suitable candidates for usage in conjunction alongside vancomycin to increase its antibacterial effect. The goal of the present research work is to boost the antibacterial potency of the glycopeptide antibiotic vancomycin towards Gram-positive (Staphylococcus aureus) but also Gram-negative (Escherichia coli) bacteria. The chemical reduction approach is used to create a colloidal solution of silver nanoparticles utilizing silver nitrate as a precursor in the environment of the ionic surfactant trisodium citrate that serves as covering including reducing reagent. Vancomycin was used to functionalize the synthesized nanoparticles and create the nanodrug complex (Van@AgNPs). The synergistic antibacterial potential of silver nanoparticles coated with vancomycin on both test pathogens was investigated using the agar well diffusion technique. The antibacterial potency for both classes of bacteria has significantly increased, according to the well diffusion test. It has been noted that this improvement is synergistic instead of additive.
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spelling pubmed-94206172022-08-30 Vancomycin as an Antibacterial Agent Capped with Silver Nanoparticles: An Experimental Potential Analysis Patwekar, Mohsina Patwekar, Faheem Alghamdi, Saad Kamal, Mehnaz Allahyani, Mamdouh Almehmadi, Mazen Kabrah, Ahmed Dablool, Anas S. Alsaiari, Ahad Amer Jawaid, Talha Medikeri, Anuradha Samuel, Krupa Islam, Fahadul Biomed Res Int Research Article For the treatment of various infections, a variety of antimicrobial drugs are formulated. Nevertheless, many bacterial infections now exhibit antibiotic resistance due to the widespread utilization antibiotics. Methicillin-resistant among the most dangerous multidrug-resistant bacteria is Staphylococcus aureus (MRSA). Vancomycin became a viable therapy option due to MRSA resistance to methicillin medicines. One of the well-informed antibacterial compounds with wideband antibacterial activity is silver nanoparticles (AgNPs). AgNPs are thus suitable candidates for usage in conjunction alongside vancomycin to increase its antibacterial effect. The goal of the present research work is to boost the antibacterial potency of the glycopeptide antibiotic vancomycin towards Gram-positive (Staphylococcus aureus) but also Gram-negative (Escherichia coli) bacteria. The chemical reduction approach is used to create a colloidal solution of silver nanoparticles utilizing silver nitrate as a precursor in the environment of the ionic surfactant trisodium citrate that serves as covering including reducing reagent. Vancomycin was used to functionalize the synthesized nanoparticles and create the nanodrug complex (Van@AgNPs). The synergistic antibacterial potential of silver nanoparticles coated with vancomycin on both test pathogens was investigated using the agar well diffusion technique. The antibacterial potency for both classes of bacteria has significantly increased, according to the well diffusion test. It has been noted that this improvement is synergistic instead of additive. Hindawi 2022-08-21 /pmc/articles/PMC9420617/ /pubmed/36046462 http://dx.doi.org/10.1155/2022/3682757 Text en Copyright © 2022 Mohsina Patwekar et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Patwekar, Mohsina
Patwekar, Faheem
Alghamdi, Saad
Kamal, Mehnaz
Allahyani, Mamdouh
Almehmadi, Mazen
Kabrah, Ahmed
Dablool, Anas S.
Alsaiari, Ahad Amer
Jawaid, Talha
Medikeri, Anuradha
Samuel, Krupa
Islam, Fahadul
Vancomycin as an Antibacterial Agent Capped with Silver Nanoparticles: An Experimental Potential Analysis
title Vancomycin as an Antibacterial Agent Capped with Silver Nanoparticles: An Experimental Potential Analysis
title_full Vancomycin as an Antibacterial Agent Capped with Silver Nanoparticles: An Experimental Potential Analysis
title_fullStr Vancomycin as an Antibacterial Agent Capped with Silver Nanoparticles: An Experimental Potential Analysis
title_full_unstemmed Vancomycin as an Antibacterial Agent Capped with Silver Nanoparticles: An Experimental Potential Analysis
title_short Vancomycin as an Antibacterial Agent Capped with Silver Nanoparticles: An Experimental Potential Analysis
title_sort vancomycin as an antibacterial agent capped with silver nanoparticles: an experimental potential analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420617/
https://www.ncbi.nlm.nih.gov/pubmed/36046462
http://dx.doi.org/10.1155/2022/3682757
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