Efficacy of RTS,S/AS01(E) malaria vaccine administered according to different full, fractional, and delayed third or early fourth dose regimens in children aged 5–17 months in Ghana and Kenya: an open-label, phase 2b, randomised controlled trial

BACKGROUND: Controlled infection studies in malaria-naive adults suggest increased vaccine efficacy for fractional-dose versus full-dose regimens of RTS,S/AS01. We report first results of an ongoing trial assessing different fractional-dose regimens in children, in natural exposure settings. METHODS...

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Detalles Bibliográficos
Autores principales: Samuels, Aaron M, Ansong, Daniel, Kariuki, Simon K, Adjei, Samuel, Bollaerts, Anne, Ockenhouse, Christian, Westercamp, Nelli, Lee, Cynthia K, Schuerman, Lode, Bii, Dennis K, Osei-Tutu, Lawrence, Oneko, Martina, Lievens, Marc, Attobrah Sarfo, Maame Anima, Atieno, Cecilia, Morelle, Danielle, Bakari, Ashura, Sang, Tony, Jongert, Erik, Kotoh-Mortty, Maame Fremah, Otieno, Kephas, Roman, François, Buabeng, Patrick Boakye Yiadom, Ntiamoah, Yaw, Ofori-Anyinam, Opokua, Agbenyega, Tsiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science ;, The Lancet Pub. Group 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420828/
https://www.ncbi.nlm.nih.gov/pubmed/35753316
http://dx.doi.org/10.1016/S1473-3099(22)00273-0

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