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The relationship between axial length/corneal radius of curvature ratio and stress–strain index in myopic eyeballs: Using Corvis ST tonometry
Purpose: This study aimed to investigate the correlation of axial length/corneal radius of curvature ratio with stress–strain index (SSI). Methods: Retrospective analysis was conducted to compare the right eyes of those with high myopia (HM, n = 132; age and 10–48 years) with those without high myop...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420864/ https://www.ncbi.nlm.nih.gov/pubmed/36046672 http://dx.doi.org/10.3389/fbioe.2022.939129 |
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author | Chu, Zhe Ren, Qi Chen, Meizhen Cheng, Lu Cheng, Hao Cui, Wei Bi, Wenjiao Wu, Jie |
author_facet | Chu, Zhe Ren, Qi Chen, Meizhen Cheng, Lu Cheng, Hao Cui, Wei Bi, Wenjiao Wu, Jie |
author_sort | Chu, Zhe |
collection | PubMed |
description | Purpose: This study aimed to investigate the correlation of axial length/corneal radius of curvature ratio with stress–strain index (SSI). Methods: Retrospective analysis was conducted to compare the right eyes of those with high myopia (HM, n = 132; age and 10–48 years) with those without high myopia (NHM, n = 135; age and 7–48 years), where the baseline axial length, corneal radius of curvature ratio, and central corneal thickness were analyzed; the differences in two groups were compared; and the relationship of axial length and axial length/corneal radius of curvature ratio with SSI were explored. Results: Compared with AL < 26mm, SSI significantly decreased when AL ≥ 26 mm (p = 0.001), while there was no correlation with AL in the NHM group (r = -0.14, p = 0.12) or HM group (r = -0.09, p = 0.32). AL/CR was significantly associated with SSI in both the NHM (r = -0.4, p < 0.001) and HM (r = -0.18, p = 0.04) groups. In the NHM group, AL/CR was significantly associated with SSI (unstandardized beta = -0.514, se = 0.109, p < 0.001) with the adjustment of age and gender. Additionally, a significant association of SSI with AL/CR was also found after adjusting for age and gender (unstandardized beta = -0.258, se = 0.096, and p = 0.0082) in the HM group. Conclusion: SSI showed a significant negative correlation with AL/CR in patients without high myopia and in patients with high myopia. However, SSI exhibited no decrease with the worsening of myopia, but it gradually remained stable at a low level. The findings of this study validate, to some extent, the possibility of analyzing the dynamic changes in ocular wall stiffness during the development of myopia by measuring in vivo corneal biomechanical parameters. |
format | Online Article Text |
id | pubmed-9420864 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94208642022-08-30 The relationship between axial length/corneal radius of curvature ratio and stress–strain index in myopic eyeballs: Using Corvis ST tonometry Chu, Zhe Ren, Qi Chen, Meizhen Cheng, Lu Cheng, Hao Cui, Wei Bi, Wenjiao Wu, Jie Front Bioeng Biotechnol Bioengineering and Biotechnology Purpose: This study aimed to investigate the correlation of axial length/corneal radius of curvature ratio with stress–strain index (SSI). Methods: Retrospective analysis was conducted to compare the right eyes of those with high myopia (HM, n = 132; age and 10–48 years) with those without high myopia (NHM, n = 135; age and 7–48 years), where the baseline axial length, corneal radius of curvature ratio, and central corneal thickness were analyzed; the differences in two groups were compared; and the relationship of axial length and axial length/corneal radius of curvature ratio with SSI were explored. Results: Compared with AL < 26mm, SSI significantly decreased when AL ≥ 26 mm (p = 0.001), while there was no correlation with AL in the NHM group (r = -0.14, p = 0.12) or HM group (r = -0.09, p = 0.32). AL/CR was significantly associated with SSI in both the NHM (r = -0.4, p < 0.001) and HM (r = -0.18, p = 0.04) groups. In the NHM group, AL/CR was significantly associated with SSI (unstandardized beta = -0.514, se = 0.109, p < 0.001) with the adjustment of age and gender. Additionally, a significant association of SSI with AL/CR was also found after adjusting for age and gender (unstandardized beta = -0.258, se = 0.096, and p = 0.0082) in the HM group. Conclusion: SSI showed a significant negative correlation with AL/CR in patients without high myopia and in patients with high myopia. However, SSI exhibited no decrease with the worsening of myopia, but it gradually remained stable at a low level. The findings of this study validate, to some extent, the possibility of analyzing the dynamic changes in ocular wall stiffness during the development of myopia by measuring in vivo corneal biomechanical parameters. Frontiers Media S.A. 2022-08-15 /pmc/articles/PMC9420864/ /pubmed/36046672 http://dx.doi.org/10.3389/fbioe.2022.939129 Text en Copyright © 2022 Chu, Ren, Chen, Cheng, Cheng, Cui, Bi and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Chu, Zhe Ren, Qi Chen, Meizhen Cheng, Lu Cheng, Hao Cui, Wei Bi, Wenjiao Wu, Jie The relationship between axial length/corneal radius of curvature ratio and stress–strain index in myopic eyeballs: Using Corvis ST tonometry |
title | The relationship between axial length/corneal radius of curvature ratio and stress–strain index in myopic eyeballs: Using Corvis ST tonometry |
title_full | The relationship between axial length/corneal radius of curvature ratio and stress–strain index in myopic eyeballs: Using Corvis ST tonometry |
title_fullStr | The relationship between axial length/corneal radius of curvature ratio and stress–strain index in myopic eyeballs: Using Corvis ST tonometry |
title_full_unstemmed | The relationship between axial length/corneal radius of curvature ratio and stress–strain index in myopic eyeballs: Using Corvis ST tonometry |
title_short | The relationship between axial length/corneal radius of curvature ratio and stress–strain index in myopic eyeballs: Using Corvis ST tonometry |
title_sort | relationship between axial length/corneal radius of curvature ratio and stress–strain index in myopic eyeballs: using corvis st tonometry |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420864/ https://www.ncbi.nlm.nih.gov/pubmed/36046672 http://dx.doi.org/10.3389/fbioe.2022.939129 |
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