A synthetic BBB-permeable tripeptide GCF confers neuroprotection by increasing glycine in the ischemic brain

Background: We and others have previously demonstrated that glycine is neuroprotective in cerebral ischemia-reperfusion injury. But glycine has low permeability to the blood–brain barrier (BBB). To deliver glycine into the ischemic brain to confer neuroprotection, we designed a novel glycine-contain...

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Detalles Bibliográficos
Autores principales: Chen, Juan, Zhuang, Yang, Zhang, Ya, Liao, Huabao, Liu, Rui, Cheng, Jing, Zhang, Zhifeng, Sun, Jiangdong, Gao, Jingchen, Wang, Xiyuran, Chen, Shujun, Zhang, Liang, Che, Fengyuan, Wan, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420865/
https://www.ncbi.nlm.nih.gov/pubmed/36046828
http://dx.doi.org/10.3389/fphar.2022.950376

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