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Aggregatibacter actinomycetemcomitans and Filifactor alocis: Two exotoxin-producing oral pathogens

Periodontitis is a dysbiotic disease caused by the interplay between the microbial ecosystem present in the disease with the dysregulated host immune response. The disease-associated microbial community is formed by the presence of established oral pathogens like Aggregatibacter actinomycetemcomitan...

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Autores principales: Ozuna, Hazel, Snider, Ian, Belibasakis, Georgios N., Oscarsson, Jan, Johansson, Anders, Uriarte, Silvia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420871/
https://www.ncbi.nlm.nih.gov/pubmed/36046121
http://dx.doi.org/10.3389/froh.2022.981343
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author Ozuna, Hazel
Snider, Ian
Belibasakis, Georgios N.
Oscarsson, Jan
Johansson, Anders
Uriarte, Silvia M.
author_facet Ozuna, Hazel
Snider, Ian
Belibasakis, Georgios N.
Oscarsson, Jan
Johansson, Anders
Uriarte, Silvia M.
author_sort Ozuna, Hazel
collection PubMed
description Periodontitis is a dysbiotic disease caused by the interplay between the microbial ecosystem present in the disease with the dysregulated host immune response. The disease-associated microbial community is formed by the presence of established oral pathogens like Aggregatibacter actinomycetemcomitans as well as by newly dominant species like Filifactor alocis. These two oral pathogens prevail and grow within the periodontal pocket which highlights their ability to evade the host immune response. This review focuses on the virulence factors and potential pathogenicity of both oral pathogens in periodontitis, accentuating the recent description of F. alocis virulence factors, including the presence of an exotoxin, and comparing them with the defined factors associated with A. actinomycetemcomitans. In the disease setting, possible synergistic and/or mutualistic interactions among both oral pathogens might contribute to disease progression.
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spelling pubmed-94208712022-08-30 Aggregatibacter actinomycetemcomitans and Filifactor alocis: Two exotoxin-producing oral pathogens Ozuna, Hazel Snider, Ian Belibasakis, Georgios N. Oscarsson, Jan Johansson, Anders Uriarte, Silvia M. Front Oral Health Oral Health Periodontitis is a dysbiotic disease caused by the interplay between the microbial ecosystem present in the disease with the dysregulated host immune response. The disease-associated microbial community is formed by the presence of established oral pathogens like Aggregatibacter actinomycetemcomitans as well as by newly dominant species like Filifactor alocis. These two oral pathogens prevail and grow within the periodontal pocket which highlights their ability to evade the host immune response. This review focuses on the virulence factors and potential pathogenicity of both oral pathogens in periodontitis, accentuating the recent description of F. alocis virulence factors, including the presence of an exotoxin, and comparing them with the defined factors associated with A. actinomycetemcomitans. In the disease setting, possible synergistic and/or mutualistic interactions among both oral pathogens might contribute to disease progression. Frontiers Media S.A. 2022-08-15 /pmc/articles/PMC9420871/ /pubmed/36046121 http://dx.doi.org/10.3389/froh.2022.981343 Text en Copyright © 2022 Ozuna, Snider, Belibasakis, Oscarsson, Johansson and Uriarte. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oral Health
Ozuna, Hazel
Snider, Ian
Belibasakis, Georgios N.
Oscarsson, Jan
Johansson, Anders
Uriarte, Silvia M.
Aggregatibacter actinomycetemcomitans and Filifactor alocis: Two exotoxin-producing oral pathogens
title Aggregatibacter actinomycetemcomitans and Filifactor alocis: Two exotoxin-producing oral pathogens
title_full Aggregatibacter actinomycetemcomitans and Filifactor alocis: Two exotoxin-producing oral pathogens
title_fullStr Aggregatibacter actinomycetemcomitans and Filifactor alocis: Two exotoxin-producing oral pathogens
title_full_unstemmed Aggregatibacter actinomycetemcomitans and Filifactor alocis: Two exotoxin-producing oral pathogens
title_short Aggregatibacter actinomycetemcomitans and Filifactor alocis: Two exotoxin-producing oral pathogens
title_sort aggregatibacter actinomycetemcomitans and filifactor alocis: two exotoxin-producing oral pathogens
topic Oral Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420871/
https://www.ncbi.nlm.nih.gov/pubmed/36046121
http://dx.doi.org/10.3389/froh.2022.981343
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