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Calibration and validation of the Pneumonia Shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study

BACKGROUND: Prognostic tools developed to stratify critically ill patients in Intensive Care Units (ICUs), are critical to predict those with higher risk of mortality in the first hours of admission. This study aims to evaluate the performance of the pShock score in critically ill patients admitted...

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Autores principales: Carmo, Thomas A., Ferreira, Isabella B. B., Menezes, Rodrigo C., Pina, Márcio L. T., Oliveira, Roberto S., Telles, Gabriel P., Machado, Antônio F. A., Aguiar, Tércio C., Caldas, Juliana R., Arriaga, María B., Akrami, Kevan M., Filgueiras Filho, Nivaldo M., Andrade, Bruno B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420902/
https://www.ncbi.nlm.nih.gov/pubmed/36045919
http://dx.doi.org/10.3389/fmed.2022.958291
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author Carmo, Thomas A.
Ferreira, Isabella B. B.
Menezes, Rodrigo C.
Pina, Márcio L. T.
Oliveira, Roberto S.
Telles, Gabriel P.
Machado, Antônio F. A.
Aguiar, Tércio C.
Caldas, Juliana R.
Arriaga, María B.
Akrami, Kevan M.
Filgueiras Filho, Nivaldo M.
Andrade, Bruno B.
author_facet Carmo, Thomas A.
Ferreira, Isabella B. B.
Menezes, Rodrigo C.
Pina, Márcio L. T.
Oliveira, Roberto S.
Telles, Gabriel P.
Machado, Antônio F. A.
Aguiar, Tércio C.
Caldas, Juliana R.
Arriaga, María B.
Akrami, Kevan M.
Filgueiras Filho, Nivaldo M.
Andrade, Bruno B.
author_sort Carmo, Thomas A.
collection PubMed
description BACKGROUND: Prognostic tools developed to stratify critically ill patients in Intensive Care Units (ICUs), are critical to predict those with higher risk of mortality in the first hours of admission. This study aims to evaluate the performance of the pShock score in critically ill patients admitted to the ICU with SARS-CoV-2 infection. METHODS: Prospective observational analytical cohort study conducted between January 2020 and March 2021 in four general ICUs in Salvador, Brazil. Descriptive statistics were used to characterize the cohort and a logistic regression, followed by cross-validation, were performed to calibrate the score. A ROC curve analysis was used to assess accuracy of the models analyzed. RESULTS: Six hundred five adult ICU patients were included in the study. The median age was 63 (IQR: 49–74) years with a mortality rate of 33.2% (201 patients). The calibrated pShock-CoV score performed well in prediction of ICU mortality (AUC of 0.80 [95% Confidence Interval (CI): 0.77–0.83; p-value < 0.0001]). CONCLUSIONS: The pShock-CoV score demonstrated robust discriminatory capacity and may assist in targeting scarce ICU resources during the COVID-19 pandemic to those critically ill patients most likely to benefit.
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spelling pubmed-94209022022-08-30 Calibration and validation of the Pneumonia Shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study Carmo, Thomas A. Ferreira, Isabella B. B. Menezes, Rodrigo C. Pina, Márcio L. T. Oliveira, Roberto S. Telles, Gabriel P. Machado, Antônio F. A. Aguiar, Tércio C. Caldas, Juliana R. Arriaga, María B. Akrami, Kevan M. Filgueiras Filho, Nivaldo M. Andrade, Bruno B. Front Med (Lausanne) Medicine BACKGROUND: Prognostic tools developed to stratify critically ill patients in Intensive Care Units (ICUs), are critical to predict those with higher risk of mortality in the first hours of admission. This study aims to evaluate the performance of the pShock score in critically ill patients admitted to the ICU with SARS-CoV-2 infection. METHODS: Prospective observational analytical cohort study conducted between January 2020 and March 2021 in four general ICUs in Salvador, Brazil. Descriptive statistics were used to characterize the cohort and a logistic regression, followed by cross-validation, were performed to calibrate the score. A ROC curve analysis was used to assess accuracy of the models analyzed. RESULTS: Six hundred five adult ICU patients were included in the study. The median age was 63 (IQR: 49–74) years with a mortality rate of 33.2% (201 patients). The calibrated pShock-CoV score performed well in prediction of ICU mortality (AUC of 0.80 [95% Confidence Interval (CI): 0.77–0.83; p-value < 0.0001]). CONCLUSIONS: The pShock-CoV score demonstrated robust discriminatory capacity and may assist in targeting scarce ICU resources during the COVID-19 pandemic to those critically ill patients most likely to benefit. Frontiers Media S.A. 2022-08-15 /pmc/articles/PMC9420902/ /pubmed/36045919 http://dx.doi.org/10.3389/fmed.2022.958291 Text en Copyright © 2022 Carmo, Ferreira, Menezes, Pina, Oliveira, Telles, Machado, Aguiar, Caldas, Arriaga, Akrami, Filgueiras Filho and Andrade. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Carmo, Thomas A.
Ferreira, Isabella B. B.
Menezes, Rodrigo C.
Pina, Márcio L. T.
Oliveira, Roberto S.
Telles, Gabriel P.
Machado, Antônio F. A.
Aguiar, Tércio C.
Caldas, Juliana R.
Arriaga, María B.
Akrami, Kevan M.
Filgueiras Filho, Nivaldo M.
Andrade, Bruno B.
Calibration and validation of the Pneumonia Shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study
title Calibration and validation of the Pneumonia Shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study
title_full Calibration and validation of the Pneumonia Shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study
title_fullStr Calibration and validation of the Pneumonia Shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study
title_full_unstemmed Calibration and validation of the Pneumonia Shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study
title_short Calibration and validation of the Pneumonia Shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study
title_sort calibration and validation of the pneumonia shock score in critically ill patients with sars-cov-2 infection, a multicenter prospective cohort study
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420902/
https://www.ncbi.nlm.nih.gov/pubmed/36045919
http://dx.doi.org/10.3389/fmed.2022.958291
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