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Case Report: Adaptive radiotherapy in the radiation salvage of prostate cancer
Adaptive radiotherapy has the potential to reduce margins, improve target coverage, and decrease toxicity to organs at risk (OARs) by optimizing radiation delivery to daily anatomic changes. Salvage for locally recurrent prostate cancer after definitive radiation remains a challenging clinical scena...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420944/ https://www.ncbi.nlm.nih.gov/pubmed/36046047 http://dx.doi.org/10.3389/fonc.2022.898822 |
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author | Montalvo, Steven K. Meng, Boyu Lin, Mu-Han Park, Chunjoo Desai, Neil B. Hannan, Raquibul Garant, Aurelie |
author_facet | Montalvo, Steven K. Meng, Boyu Lin, Mu-Han Park, Chunjoo Desai, Neil B. Hannan, Raquibul Garant, Aurelie |
author_sort | Montalvo, Steven K. |
collection | PubMed |
description | Adaptive radiotherapy has the potential to reduce margins, improve target coverage, and decrease toxicity to organs at risk (OARs) by optimizing radiation delivery to daily anatomic changes. Salvage for locally recurrent prostate cancer after definitive radiation remains a challenging clinical scenario given the risks to normal tissue in a setting of re-irradiation. Here, we present a case series of five patients with locally recurrent prostate cancer treated with an adaptive online linear accelerator or a 3-T MR-based linear accelerator to demonstrate excellent target coverage. All patients completed the planned treatment course with acceptable acute toxicities but a short follow-up time does not inform subacute/late toxicities. |
format | Online Article Text |
id | pubmed-9420944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94209442022-08-30 Case Report: Adaptive radiotherapy in the radiation salvage of prostate cancer Montalvo, Steven K. Meng, Boyu Lin, Mu-Han Park, Chunjoo Desai, Neil B. Hannan, Raquibul Garant, Aurelie Front Oncol Oncology Adaptive radiotherapy has the potential to reduce margins, improve target coverage, and decrease toxicity to organs at risk (OARs) by optimizing radiation delivery to daily anatomic changes. Salvage for locally recurrent prostate cancer after definitive radiation remains a challenging clinical scenario given the risks to normal tissue in a setting of re-irradiation. Here, we present a case series of five patients with locally recurrent prostate cancer treated with an adaptive online linear accelerator or a 3-T MR-based linear accelerator to demonstrate excellent target coverage. All patients completed the planned treatment course with acceptable acute toxicities but a short follow-up time does not inform subacute/late toxicities. Frontiers Media S.A. 2022-08-15 /pmc/articles/PMC9420944/ /pubmed/36046047 http://dx.doi.org/10.3389/fonc.2022.898822 Text en Copyright © 2022 Montalvo, Meng, Lin, Park, Desai, Hannan and Garant https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Montalvo, Steven K. Meng, Boyu Lin, Mu-Han Park, Chunjoo Desai, Neil B. Hannan, Raquibul Garant, Aurelie Case Report: Adaptive radiotherapy in the radiation salvage of prostate cancer |
title | Case Report: Adaptive radiotherapy in the radiation salvage of prostate cancer |
title_full | Case Report: Adaptive radiotherapy in the radiation salvage of prostate cancer |
title_fullStr | Case Report: Adaptive radiotherapy in the radiation salvage of prostate cancer |
title_full_unstemmed | Case Report: Adaptive radiotherapy in the radiation salvage of prostate cancer |
title_short | Case Report: Adaptive radiotherapy in the radiation salvage of prostate cancer |
title_sort | case report: adaptive radiotherapy in the radiation salvage of prostate cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420944/ https://www.ncbi.nlm.nih.gov/pubmed/36046047 http://dx.doi.org/10.3389/fonc.2022.898822 |
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