The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR

OBJECTIVE: The mitochondrial fission protein Drp1 was proposed to promote NAFLD, as inhibition of hepatocyte Drp1 early in life prevents liver steatosis induced by high-fat diet in mice. However, whether Drp1-knockdown in older mice can reverse established NASH is unknown. METHODS: N-acetylgalactosa...

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Detalles Bibliográficos
Autores principales: Steffen, Janos, Ngo, Jennifer, Wang, Sheng-Ping, Williams, Kevin, Kramer, Henning F., Ho, George, Rodriguez, Carlos, Yekkala, Krishna, Amuzie, Chidozie, Bialecki, Russell, Norquay, Lisa, Nawrocki, Andrea R., Erion, Mark, Pocai, Alessandro, Shirihai, Orian S., Liesa, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420962/
https://www.ncbi.nlm.nih.gov/pubmed/35940556
http://dx.doi.org/10.1016/j.molmet.2022.101566

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