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A review for the pharmacological effects of paeoniflorin in the nervous system

Paeoniflorin, a terpenoid glycoside compound extracted from Paeonia lactiflora Pall, shows preventive and therapeutic effects in various types of nervous system disorders. However, to date, no comprehensive knowledge on the pharmacological effects of paeoniflorin on the nervous system is available o...

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Autores principales: Hong, Hongxiang, Lu, Xu, Wu, Chunshuai, Chen, Jiajia, Chen, Chu, Zhang, Jinlong, Huang, Chao, Cui, Zhiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420976/
https://www.ncbi.nlm.nih.gov/pubmed/36046834
http://dx.doi.org/10.3389/fphar.2022.898955
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author Hong, Hongxiang
Lu, Xu
Wu, Chunshuai
Chen, Jiajia
Chen, Chu
Zhang, Jinlong
Huang, Chao
Cui, Zhiming
author_facet Hong, Hongxiang
Lu, Xu
Wu, Chunshuai
Chen, Jiajia
Chen, Chu
Zhang, Jinlong
Huang, Chao
Cui, Zhiming
author_sort Hong, Hongxiang
collection PubMed
description Paeoniflorin, a terpenoid glycoside compound extracted from Paeonia lactiflora Pall, shows preventive and therapeutic effects in various types of nervous system disorders. However, to date, no comprehensive knowledge on the pharmacological effects of paeoniflorin on the nervous system is available online. Clarification of this issue may be useful for the development of paeoniflorin as a new drug for the treatment of nervous system disorders. To this end, the authors summarize the pharmacological aspects of paeoniflorin and its possible mechanisms, such as restoration of mitochondrial function; inhibition of neuroinflammation, oxidative stress, and cellular apoptosis; activation of adenosine A1 receptor, cAMP response element-binding protein (CREB) and extracellular signal-regulated kinase 1/2 (ERK1/2); or enhancement of brain-derived neurotrophic factor and serotonin function, in the prevention of disorders such as cerebral ischemia, subarachnoid hemorrhage, vascular dementia, Alzheimer’s disease, Parkinson’s disease, depression, post-traumatic syndrome disorder, and epilepsy, by reviewing the previously published literature.
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spelling pubmed-94209762022-08-30 A review for the pharmacological effects of paeoniflorin in the nervous system Hong, Hongxiang Lu, Xu Wu, Chunshuai Chen, Jiajia Chen, Chu Zhang, Jinlong Huang, Chao Cui, Zhiming Front Pharmacol Pharmacology Paeoniflorin, a terpenoid glycoside compound extracted from Paeonia lactiflora Pall, shows preventive and therapeutic effects in various types of nervous system disorders. However, to date, no comprehensive knowledge on the pharmacological effects of paeoniflorin on the nervous system is available online. Clarification of this issue may be useful for the development of paeoniflorin as a new drug for the treatment of nervous system disorders. To this end, the authors summarize the pharmacological aspects of paeoniflorin and its possible mechanisms, such as restoration of mitochondrial function; inhibition of neuroinflammation, oxidative stress, and cellular apoptosis; activation of adenosine A1 receptor, cAMP response element-binding protein (CREB) and extracellular signal-regulated kinase 1/2 (ERK1/2); or enhancement of brain-derived neurotrophic factor and serotonin function, in the prevention of disorders such as cerebral ischemia, subarachnoid hemorrhage, vascular dementia, Alzheimer’s disease, Parkinson’s disease, depression, post-traumatic syndrome disorder, and epilepsy, by reviewing the previously published literature. Frontiers Media S.A. 2022-08-15 /pmc/articles/PMC9420976/ /pubmed/36046834 http://dx.doi.org/10.3389/fphar.2022.898955 Text en Copyright © 2022 Hong, Lu, Wu, Chen, Chen, Zhang, Huang and Cui. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Hong, Hongxiang
Lu, Xu
Wu, Chunshuai
Chen, Jiajia
Chen, Chu
Zhang, Jinlong
Huang, Chao
Cui, Zhiming
A review for the pharmacological effects of paeoniflorin in the nervous system
title A review for the pharmacological effects of paeoniflorin in the nervous system
title_full A review for the pharmacological effects of paeoniflorin in the nervous system
title_fullStr A review for the pharmacological effects of paeoniflorin in the nervous system
title_full_unstemmed A review for the pharmacological effects of paeoniflorin in the nervous system
title_short A review for the pharmacological effects of paeoniflorin in the nervous system
title_sort review for the pharmacological effects of paeoniflorin in the nervous system
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420976/
https://www.ncbi.nlm.nih.gov/pubmed/36046834
http://dx.doi.org/10.3389/fphar.2022.898955
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