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Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells
Hypoxia is a common hallmark of healthy tissues in physiological states or chronically inflamed tissues in pathological states. Mammalian cells sense and adapt to hypoxia mainly through hypoxia-inducible factor (HIF) signaling. Many studies have shown that hypoxia and HIF signaling play an important...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421003/ https://www.ncbi.nlm.nih.gov/pubmed/36045669 http://dx.doi.org/10.3389/fimmu.2022.967576 |
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author | Zhang, Jinwei Wu, Xiaoqian Ma, Jideng Long, Keren Sun, Jing Li, Mingzhou Ge, Liangpeng |
author_facet | Zhang, Jinwei Wu, Xiaoqian Ma, Jideng Long, Keren Sun, Jing Li, Mingzhou Ge, Liangpeng |
author_sort | Zhang, Jinwei |
collection | PubMed |
description | Hypoxia is a common hallmark of healthy tissues in physiological states or chronically inflamed tissues in pathological states. Mammalian cells sense and adapt to hypoxia mainly through hypoxia-inducible factor (HIF) signaling. Many studies have shown that hypoxia and HIF signaling play an important regulatory role in development and function of innate immune cells and T cells, but their role in B cell biology is still controversial. B cells experience a complex life cycle (including hematopoietic stem cells, pro-B cells, pre-B cells, immature B cells, mature naïve B cells, activated B cells, plasma cells, and memory B cells), and the partial pressure of oxygen (PO(2)) in the corresponding developmental niche of stage-specific B cells is highly dynamic, which suggests that hypoxia and HIF signaling may play an indispensable role in B cell biology. Based on the fact that hypoxia niches exist in the B cell life cycle, this review focuses on recent discoveries about how hypoxia and HIF signaling regulate the development, metabolism, and function of B cells, to facilitate a deep understanding of the role of hypoxia in B cell-mediated adaptive immunity and to provide novel strategies for vaccine adjuvant research and the treatment of immunity-related or infectious diseases. |
format | Online Article Text |
id | pubmed-9421003 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94210032022-08-30 Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells Zhang, Jinwei Wu, Xiaoqian Ma, Jideng Long, Keren Sun, Jing Li, Mingzhou Ge, Liangpeng Front Immunol Immunology Hypoxia is a common hallmark of healthy tissues in physiological states or chronically inflamed tissues in pathological states. Mammalian cells sense and adapt to hypoxia mainly through hypoxia-inducible factor (HIF) signaling. Many studies have shown that hypoxia and HIF signaling play an important regulatory role in development and function of innate immune cells and T cells, but their role in B cell biology is still controversial. B cells experience a complex life cycle (including hematopoietic stem cells, pro-B cells, pre-B cells, immature B cells, mature naïve B cells, activated B cells, plasma cells, and memory B cells), and the partial pressure of oxygen (PO(2)) in the corresponding developmental niche of stage-specific B cells is highly dynamic, which suggests that hypoxia and HIF signaling may play an indispensable role in B cell biology. Based on the fact that hypoxia niches exist in the B cell life cycle, this review focuses on recent discoveries about how hypoxia and HIF signaling regulate the development, metabolism, and function of B cells, to facilitate a deep understanding of the role of hypoxia in B cell-mediated adaptive immunity and to provide novel strategies for vaccine adjuvant research and the treatment of immunity-related or infectious diseases. Frontiers Media S.A. 2022-08-15 /pmc/articles/PMC9421003/ /pubmed/36045669 http://dx.doi.org/10.3389/fimmu.2022.967576 Text en Copyright © 2022 Zhang, Wu, Ma, Long, Sun, Li and Ge https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhang, Jinwei Wu, Xiaoqian Ma, Jideng Long, Keren Sun, Jing Li, Mingzhou Ge, Liangpeng Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells |
title | Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells |
title_full | Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells |
title_fullStr | Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells |
title_full_unstemmed | Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells |
title_short | Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells |
title_sort | hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of b cells |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421003/ https://www.ncbi.nlm.nih.gov/pubmed/36045669 http://dx.doi.org/10.3389/fimmu.2022.967576 |
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