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Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris

Candida auris is an emerging global public health threat. It is an opportunistic yeast that usually affects critically ill patients in healthcare settings and is characterized by reduced susceptibility to multiple antifungal classes. Combination therapy with antifungals and repurposed drugs is a fea...

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Autores principales: Alanís-Ríos, Sergio A., González, Gloria M., Andrade, Angel, Becerril-García, Miguel A., Bonifaz, Alexandro, Robledo-Leal, Efrén R., Montoya, Alexandra M., Treviño-Rangel, Rogelio de J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421114/
https://www.ncbi.nlm.nih.gov/pubmed/36036298
http://dx.doi.org/10.1007/s42770-022-00817-y
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author Alanís-Ríos, Sergio A.
González, Gloria M.
Andrade, Angel
Becerril-García, Miguel A.
Bonifaz, Alexandro
Robledo-Leal, Efrén R.
Montoya, Alexandra M.
Treviño-Rangel, Rogelio de J.
author_facet Alanís-Ríos, Sergio A.
González, Gloria M.
Andrade, Angel
Becerril-García, Miguel A.
Bonifaz, Alexandro
Robledo-Leal, Efrén R.
Montoya, Alexandra M.
Treviño-Rangel, Rogelio de J.
author_sort Alanís-Ríos, Sergio A.
collection PubMed
description Candida auris is an emerging global public health threat. It is an opportunistic yeast that usually affects critically ill patients in healthcare settings and is characterized by reduced susceptibility to multiple antifungal classes. Combination therapy with antifungals and repurposed drugs is a feasible alternative to overcome this problem. The aim of this study was to examine the in vitro interactions and potential synergy of micafungin (MFG) and voriconazole (VRC) plus the antidepressant sertraline (SRT) against clinical isolates of C. auris. Conventional antifungal testing was first performed with the three drugs according to the CLSI methodology. Drug interactions were determined by the checkerboard microdilution assay using the fractional inhibitory concentration (FIC) index. Synergistic interactions were noted with the combination of MFG and SRT plus VRC with FIC values of 0.37 to 0.49 for some strains. Indifferent interactions were observed when MFG was combined with SRT with just one exception (FIC 0.53). No antagonism was observed for any combination. The combination of VRC with MCF or SRT may be relevant for treating C. auris infections.
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spelling pubmed-94211142022-08-30 Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris Alanís-Ríos, Sergio A. González, Gloria M. Andrade, Angel Becerril-García, Miguel A. Bonifaz, Alexandro Robledo-Leal, Efrén R. Montoya, Alexandra M. Treviño-Rangel, Rogelio de J. Braz J Microbiol Clinical Microbiology - Short Communication Candida auris is an emerging global public health threat. It is an opportunistic yeast that usually affects critically ill patients in healthcare settings and is characterized by reduced susceptibility to multiple antifungal classes. Combination therapy with antifungals and repurposed drugs is a feasible alternative to overcome this problem. The aim of this study was to examine the in vitro interactions and potential synergy of micafungin (MFG) and voriconazole (VRC) plus the antidepressant sertraline (SRT) against clinical isolates of C. auris. Conventional antifungal testing was first performed with the three drugs according to the CLSI methodology. Drug interactions were determined by the checkerboard microdilution assay using the fractional inhibitory concentration (FIC) index. Synergistic interactions were noted with the combination of MFG and SRT plus VRC with FIC values of 0.37 to 0.49 for some strains. Indifferent interactions were observed when MFG was combined with SRT with just one exception (FIC 0.53). No antagonism was observed for any combination. The combination of VRC with MCF or SRT may be relevant for treating C. auris infections. Springer International Publishing 2022-08-29 /pmc/articles/PMC9421114/ /pubmed/36036298 http://dx.doi.org/10.1007/s42770-022-00817-y Text en © The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia 2022
spellingShingle Clinical Microbiology - Short Communication
Alanís-Ríos, Sergio A.
González, Gloria M.
Andrade, Angel
Becerril-García, Miguel A.
Bonifaz, Alexandro
Robledo-Leal, Efrén R.
Montoya, Alexandra M.
Treviño-Rangel, Rogelio de J.
Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris
title Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris
title_full Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris
title_fullStr Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris
title_full_unstemmed Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris
title_short Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris
title_sort evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against candida auris
topic Clinical Microbiology - Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421114/
https://www.ncbi.nlm.nih.gov/pubmed/36036298
http://dx.doi.org/10.1007/s42770-022-00817-y
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