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Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway

The descending pain modulatory pathway exerts important bidirectional control of nociceptive inputs to dampen and/or facilitate the perception of pain. The ventrolateral periaqueductal gray (vlPAG) integrates inputs from many regions associated with the processing of nociceptive, cognitive, and affe...

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Autores principales: McPherson, Kylie B., Ingram, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421147/
https://www.ncbi.nlm.nih.gov/pubmed/36045708
http://dx.doi.org/10.3389/fnsys.2022.963812
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author McPherson, Kylie B.
Ingram, Susan L.
author_facet McPherson, Kylie B.
Ingram, Susan L.
author_sort McPherson, Kylie B.
collection PubMed
description The descending pain modulatory pathway exerts important bidirectional control of nociceptive inputs to dampen and/or facilitate the perception of pain. The ventrolateral periaqueductal gray (vlPAG) integrates inputs from many regions associated with the processing of nociceptive, cognitive, and affective components of pain perception, and is a key brain area for opioid action. Opioid receptors are expressed on a subset of vlPAG neurons, as well as on both GABAergic and glutamatergic presynaptic terminals that impinge on vlPAG neurons. Microinjection of opioids into the vlPAG produces analgesia and microinjection of the opioid receptor antagonist naloxone blocks stimulation-mediated analgesia, highlighting the role of endogenous opioid release within this region in the modulation of nociception. Endogenous opioid effects within the vlPAG are complex and likely dependent on specific neuronal circuits activated by acute and chronic pain stimuli. This review is focused on the cellular heterogeneity within vlPAG circuits and highlights gaps in our understanding of endogenous opioid regulation of the descending pain modulatory circuits.
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spelling pubmed-94211472022-08-30 Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway McPherson, Kylie B. Ingram, Susan L. Front Syst Neurosci Neuroscience The descending pain modulatory pathway exerts important bidirectional control of nociceptive inputs to dampen and/or facilitate the perception of pain. The ventrolateral periaqueductal gray (vlPAG) integrates inputs from many regions associated with the processing of nociceptive, cognitive, and affective components of pain perception, and is a key brain area for opioid action. Opioid receptors are expressed on a subset of vlPAG neurons, as well as on both GABAergic and glutamatergic presynaptic terminals that impinge on vlPAG neurons. Microinjection of opioids into the vlPAG produces analgesia and microinjection of the opioid receptor antagonist naloxone blocks stimulation-mediated analgesia, highlighting the role of endogenous opioid release within this region in the modulation of nociception. Endogenous opioid effects within the vlPAG are complex and likely dependent on specific neuronal circuits activated by acute and chronic pain stimuli. This review is focused on the cellular heterogeneity within vlPAG circuits and highlights gaps in our understanding of endogenous opioid regulation of the descending pain modulatory circuits. Frontiers Media S.A. 2022-08-15 /pmc/articles/PMC9421147/ /pubmed/36045708 http://dx.doi.org/10.3389/fnsys.2022.963812 Text en Copyright © 2022 McPherson and Ingram. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
McPherson, Kylie B.
Ingram, Susan L.
Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway
title Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway
title_full Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway
title_fullStr Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway
title_full_unstemmed Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway
title_short Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway
title_sort cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421147/
https://www.ncbi.nlm.nih.gov/pubmed/36045708
http://dx.doi.org/10.3389/fnsys.2022.963812
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