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Biosignature of self-injury behaviors in adolescence: Role of β-endorphin in an acute inpatient unit

Self-injurious behavior (SIB) (either non-suicidal self-injury, NSSI; or suicide attempts, SA) is a common reason for adolescent psychiatric emergency hospitalizations. Altered basal serum β-endorphin (BE) levels have been reported in adults with a history of SIB, but information is lacking in adole...

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Autores principales: Wang, Ping, Li, Chao, del Sol-Calderón, Pablo, Mallol, Leticia, Hernández-Álvarez, Elena, Donoso-Navarro, Encarnación, Gil-Ligero, María, Rosado-Garcia, Silvia, Sánchez-Lòpez, Antonio José, Martín-Moratinos, Marina, Bella-Fernández, Marcos, Blasco-Fontecilla, Hilario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421366/
https://www.ncbi.nlm.nih.gov/pubmed/36046158
http://dx.doi.org/10.3389/fpsyt.2022.933275
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author Wang, Ping
Li, Chao
del Sol-Calderón, Pablo
Mallol, Leticia
Hernández-Álvarez, Elena
Donoso-Navarro, Encarnación
Gil-Ligero, María
Rosado-Garcia, Silvia
Sánchez-Lòpez, Antonio José
Martín-Moratinos, Marina
Bella-Fernández, Marcos
Blasco-Fontecilla, Hilario
author_facet Wang, Ping
Li, Chao
del Sol-Calderón, Pablo
Mallol, Leticia
Hernández-Álvarez, Elena
Donoso-Navarro, Encarnación
Gil-Ligero, María
Rosado-Garcia, Silvia
Sánchez-Lòpez, Antonio José
Martín-Moratinos, Marina
Bella-Fernández, Marcos
Blasco-Fontecilla, Hilario
author_sort Wang, Ping
collection PubMed
description Self-injurious behavior (SIB) (either non-suicidal self-injury, NSSI; or suicide attempts, SA) is a common reason for adolescent psychiatric emergency hospitalizations. Altered basal serum β-endorphin (BE) levels have been reported in adults with a history of SIB, but information is lacking in adolescents. We analyzed the psychoclinical profile and serum BE level of 39 adolescents admitted to the acute unit at a hospital in Spain due to SIB. The Mean (SD) serum BE level was high (190.53 ± 74.83). Regarding time sequence, the onset age of NSSI and SA were related (p < 0.001). The older the onset age of NSSI, the shorter the transition between NSSI and the onset of SA behavior (p = 0.05), but this difference does not lead the variation of BE (p = 0.81). Patients diagnosed with depression had lower serum BE levels than adolescents with other diagnoses (p = 0.03). Although adolescents who seem to be addicted to SIB had higher levels of BE, this finding was not statistically significant. The relationship between serum BE levels and SIB in adolescents requires further investigation.
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spelling pubmed-94213662022-08-30 Biosignature of self-injury behaviors in adolescence: Role of β-endorphin in an acute inpatient unit Wang, Ping Li, Chao del Sol-Calderón, Pablo Mallol, Leticia Hernández-Álvarez, Elena Donoso-Navarro, Encarnación Gil-Ligero, María Rosado-Garcia, Silvia Sánchez-Lòpez, Antonio José Martín-Moratinos, Marina Bella-Fernández, Marcos Blasco-Fontecilla, Hilario Front Psychiatry Psychiatry Self-injurious behavior (SIB) (either non-suicidal self-injury, NSSI; or suicide attempts, SA) is a common reason for adolescent psychiatric emergency hospitalizations. Altered basal serum β-endorphin (BE) levels have been reported in adults with a history of SIB, but information is lacking in adolescents. We analyzed the psychoclinical profile and serum BE level of 39 adolescents admitted to the acute unit at a hospital in Spain due to SIB. The Mean (SD) serum BE level was high (190.53 ± 74.83). Regarding time sequence, the onset age of NSSI and SA were related (p < 0.001). The older the onset age of NSSI, the shorter the transition between NSSI and the onset of SA behavior (p = 0.05), but this difference does not lead the variation of BE (p = 0.81). Patients diagnosed with depression had lower serum BE levels than adolescents with other diagnoses (p = 0.03). Although adolescents who seem to be addicted to SIB had higher levels of BE, this finding was not statistically significant. The relationship between serum BE levels and SIB in adolescents requires further investigation. Frontiers Media S.A. 2022-08-15 /pmc/articles/PMC9421366/ /pubmed/36046158 http://dx.doi.org/10.3389/fpsyt.2022.933275 Text en Copyright © 2022 Wang, Li, del Sol-Calderón, Mallol, Hernández-Álvarez, Donoso-Navarro, Gil-Ligero, Rosado-Garcia, Sánchez-Lòpez, Martín-Moratinos, Bella-Fernández and Blasco-Fontecilla. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Wang, Ping
Li, Chao
del Sol-Calderón, Pablo
Mallol, Leticia
Hernández-Álvarez, Elena
Donoso-Navarro, Encarnación
Gil-Ligero, María
Rosado-Garcia, Silvia
Sánchez-Lòpez, Antonio José
Martín-Moratinos, Marina
Bella-Fernández, Marcos
Blasco-Fontecilla, Hilario
Biosignature of self-injury behaviors in adolescence: Role of β-endorphin in an acute inpatient unit
title Biosignature of self-injury behaviors in adolescence: Role of β-endorphin in an acute inpatient unit
title_full Biosignature of self-injury behaviors in adolescence: Role of β-endorphin in an acute inpatient unit
title_fullStr Biosignature of self-injury behaviors in adolescence: Role of β-endorphin in an acute inpatient unit
title_full_unstemmed Biosignature of self-injury behaviors in adolescence: Role of β-endorphin in an acute inpatient unit
title_short Biosignature of self-injury behaviors in adolescence: Role of β-endorphin in an acute inpatient unit
title_sort biosignature of self-injury behaviors in adolescence: role of β-endorphin in an acute inpatient unit
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421366/
https://www.ncbi.nlm.nih.gov/pubmed/36046158
http://dx.doi.org/10.3389/fpsyt.2022.933275
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