Antagonizing Sec62 function in intracellular Ca(2+) homeostasis represents a novel therapeutic strategy for head and neck cancer

Various cancer types including head and neck squamous cell carcinomas (HNSCC) show a frequent amplification of chromosomal region 3q26 that encodes, among others, for the SEC62 gene. Located in the ER membrane, this translocation protein is known to play a critical role as a potential driver oncogen...

Descripción completa

Detalles Bibliográficos
Autores principales: Körner, Sandrina, Pick, Tillman, Bochen, Florian, Wemmert, Silke, Körbel, Christina, Menger, Michael D., Cavalié, Adolfo, Kühn, Jan-Philipp, Schick, Bernhard, Linxweiler, Maximilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421371/
https://www.ncbi.nlm.nih.gov/pubmed/36045752
http://dx.doi.org/10.3389/fphys.2022.880004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421371/
https://www.ncbi.nlm.nih.gov/pubmed/36045752
http://dx.doi.org/10.3389/fphys.2022.880004

Ejemplares similares