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Antagonizing Sec62 function in intracellular Ca(2+) homeostasis represents a novel therapeutic strategy for head and neck cancer

Various cancer types including head and neck squamous cell carcinomas (HNSCC) show a frequent amplification of chromosomal region 3q26 that encodes, among others, for the SEC62 gene. Located in the ER membrane, this translocation protein is known to play a critical role as a potential driver oncogen...

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Detalles Bibliográficos
Autores principales:	Körner, Sandrina, Pick, Tillman, Bochen, Florian, Wemmert, Silke, Körbel, Christina, Menger, Michael D., Cavalié, Adolfo, Kühn, Jan-Philipp, Schick, Bernhard, Linxweiler, Maximilian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421371/ https://www.ncbi.nlm.nih.gov/pubmed/36045752 http://dx.doi.org/10.3389/fphys.2022.880004

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