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A systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations

Hallucinations are a complex and multidimensional phenomenon which can differ based on the involved pathology, typology and sensory modality. Hallucinations are common in patients with neurodegenerative diseases. Recent sparse evidence from resting state functional magnetic resonance imaging (rs-fMR...

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Autores principales: Spinosa, Vittoria, Brattico, Elvira, Campo, Fulvia, Logroscino, Giancarlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421441/
https://www.ncbi.nlm.nih.gov/pubmed/35853345
http://dx.doi.org/10.1016/j.nicl.2022.103112
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author Spinosa, Vittoria
Brattico, Elvira
Campo, Fulvia
Logroscino, Giancarlo
author_facet Spinosa, Vittoria
Brattico, Elvira
Campo, Fulvia
Logroscino, Giancarlo
author_sort Spinosa, Vittoria
collection PubMed
description Hallucinations are a complex and multidimensional phenomenon which can differ based on the involved pathology, typology and sensory modality. Hallucinations are common in patients with neurodegenerative diseases. Recent sparse evidence from resting state functional magnetic resonance imaging (rs-fMRI) studies has identified altered functional connectivity in those patients within several brain networks, such as the default mode, attentional and sensory ones, without, however, providing an organized picture of the mechanisms involved. This systematic review, following PRISMA guidelines, aims at critically analyzing the current literature on the brain networks associated with the phenomenon of hallucinations in patients with neurodegenerative diseases. Ten rs-fMRI studies fulfilled our selection criteria. All these studies focused on synucleinopathies, and most of them focused on visual hallucinations and were characterized by a heterogeneous methodology. Thus, instead of offering a definite picture of the mechanisms underlying hallucinations in neurodegeneration, this systematic review encourages further research especially concerning tauopathies. Notwithstanding, the findings overall suggest a disruption in the top-down (associated with memory intrusion and difficulty of inhibition) and in the bottom-up processes (associated with the sensory areas involved in the hallucinations). Further investigations are needed in order to disentangle the brain mechanisms involved in hallucinations and to overcome possible limitations characterizing the current literature.
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spelling pubmed-94214412022-08-30 A systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations Spinosa, Vittoria Brattico, Elvira Campo, Fulvia Logroscino, Giancarlo Neuroimage Clin Review Article Hallucinations are a complex and multidimensional phenomenon which can differ based on the involved pathology, typology and sensory modality. Hallucinations are common in patients with neurodegenerative diseases. Recent sparse evidence from resting state functional magnetic resonance imaging (rs-fMRI) studies has identified altered functional connectivity in those patients within several brain networks, such as the default mode, attentional and sensory ones, without, however, providing an organized picture of the mechanisms involved. This systematic review, following PRISMA guidelines, aims at critically analyzing the current literature on the brain networks associated with the phenomenon of hallucinations in patients with neurodegenerative diseases. Ten rs-fMRI studies fulfilled our selection criteria. All these studies focused on synucleinopathies, and most of them focused on visual hallucinations and were characterized by a heterogeneous methodology. Thus, instead of offering a definite picture of the mechanisms underlying hallucinations in neurodegeneration, this systematic review encourages further research especially concerning tauopathies. Notwithstanding, the findings overall suggest a disruption in the top-down (associated with memory intrusion and difficulty of inhibition) and in the bottom-up processes (associated with the sensory areas involved in the hallucinations). Further investigations are needed in order to disentangle the brain mechanisms involved in hallucinations and to overcome possible limitations characterizing the current literature. Elsevier 2022-07-13 /pmc/articles/PMC9421441/ /pubmed/35853345 http://dx.doi.org/10.1016/j.nicl.2022.103112 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Spinosa, Vittoria
Brattico, Elvira
Campo, Fulvia
Logroscino, Giancarlo
A systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations
title A systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations
title_full A systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations
title_fullStr A systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations
title_full_unstemmed A systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations
title_short A systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations
title_sort systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421441/
https://www.ncbi.nlm.nih.gov/pubmed/35853345
http://dx.doi.org/10.1016/j.nicl.2022.103112
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