The unique effect of TDP-43 on hippocampal subfield morphometry and cognition

• We explored postmortem TDP-43 burden and antemortem hippocampal surface deformation. • TDP-43 was uniquely associated with inward deformation in the hippocampus. • Deformation patterns account for co-existing disease showing TDP-43′s unique effect. • Deformation was significantly correlated with c...

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Detalles Bibliográficos
Autores principales: Heywood, Ashley, Stocks, Jane, Schneider, Julie A., Arfanakis, Konstantinos, Bennett, David A., Beg, Mirza Faisal, Wang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421500/
https://www.ncbi.nlm.nih.gov/pubmed/36002965
http://dx.doi.org/10.1016/j.nicl.2022.103125
Descripción
Sumario:• We explored postmortem TDP-43 burden and antemortem hippocampal surface deformation. • TDP-43 was uniquely associated with inward deformation in the hippocampus. • Deformation patterns account for co-existing disease showing TDP-43′s unique effect. • Deformation was significantly correlated with cognition scores.

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