The unique effect of TDP-43 on hippocampal subfield morphometry and cognition

• We explored postmortem TDP-43 burden and antemortem hippocampal surface deformation. • TDP-43 was uniquely associated with inward deformation in the hippocampus. • Deformation patterns account for co-existing disease showing TDP-43′s unique effect. • Deformation was significantly correlated with c...

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Detalles Bibliográficos
Autores principales: Heywood, Ashley, Stocks, Jane, Schneider, Julie A., Arfanakis, Konstantinos, Bennett, David A., Beg, Mirza Faisal, Wang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421500/
https://www.ncbi.nlm.nih.gov/pubmed/36002965
http://dx.doi.org/10.1016/j.nicl.2022.103125
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author Heywood, Ashley
Stocks, Jane
Schneider, Julie A.
Arfanakis, Konstantinos
Bennett, David A.
Beg, Mirza Faisal
Wang, Lei
author_facet Heywood, Ashley
Stocks, Jane
Schneider, Julie A.
Arfanakis, Konstantinos
Bennett, David A.
Beg, Mirza Faisal
Wang, Lei
author_sort Heywood, Ashley
collection PubMed
description • We explored postmortem TDP-43 burden and antemortem hippocampal surface deformation. • TDP-43 was uniquely associated with inward deformation in the hippocampus. • Deformation patterns account for co-existing disease showing TDP-43′s unique effect. • Deformation was significantly correlated with cognition scores.
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spelling pubmed-94215002022-08-30 The unique effect of TDP-43 on hippocampal subfield morphometry and cognition Heywood, Ashley Stocks, Jane Schneider, Julie A. Arfanakis, Konstantinos Bennett, David A. Beg, Mirza Faisal Wang, Lei Neuroimage Clin Regular Article • We explored postmortem TDP-43 burden and antemortem hippocampal surface deformation. • TDP-43 was uniquely associated with inward deformation in the hippocampus. • Deformation patterns account for co-existing disease showing TDP-43′s unique effect. • Deformation was significantly correlated with cognition scores. Elsevier 2022-07-25 /pmc/articles/PMC9421500/ /pubmed/36002965 http://dx.doi.org/10.1016/j.nicl.2022.103125 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Heywood, Ashley
Stocks, Jane
Schneider, Julie A.
Arfanakis, Konstantinos
Bennett, David A.
Beg, Mirza Faisal
Wang, Lei
The unique effect of TDP-43 on hippocampal subfield morphometry and cognition
title The unique effect of TDP-43 on hippocampal subfield morphometry and cognition
title_full The unique effect of TDP-43 on hippocampal subfield morphometry and cognition
title_fullStr The unique effect of TDP-43 on hippocampal subfield morphometry and cognition
title_full_unstemmed The unique effect of TDP-43 on hippocampal subfield morphometry and cognition
title_short The unique effect of TDP-43 on hippocampal subfield morphometry and cognition
title_sort unique effect of tdp-43 on hippocampal subfield morphometry and cognition
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421500/
https://www.ncbi.nlm.nih.gov/pubmed/36002965
http://dx.doi.org/10.1016/j.nicl.2022.103125
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