Immune system-related soluble mediators and COVID-19: basic mechanisms and clinical perspectives

During SARS-CoV-2 infection, an effective immune response provides the first line of defense; however, excessive inflammatory innate immunity and impaired adaptive immunity may harm tissues. Soluble immune mediators are involved in the dynamic interaction of ligands with membrane-bound receptors to...

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Detalles Bibliográficos
Autores principales: Soltani-Zangbar, Mohammad Sadegh, Parhizkar, Forough, Abdollahi, Mojtaba, Shomali, Navid, Aghebati-Maleki, Leili, Shahmohammadi Farid, Sima, Roshangar, Leila, Mahmoodpoor, Ata, Yousefi, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421625/
https://www.ncbi.nlm.nih.gov/pubmed/36038915
http://dx.doi.org/10.1186/s12964-022-00948-7
Descripción
Sumario:During SARS-CoV-2 infection, an effective immune response provides the first line of defense; however, excessive inflammatory innate immunity and impaired adaptive immunity may harm tissues. Soluble immune mediators are involved in the dynamic interaction of ligands with membrane-bound receptors to maintain and restore health after pathological events. In some cases, the dysregulation of their expression can lead to disease pathology. In this literature review, we described current knowledge of the basic features of soluble immune mediators and their dysregulation during SARS-CoV-2 infections and highlighted their contribution to disease severity and mortality. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00948-7.

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