Immune system-related soluble mediators and COVID-19: basic mechanisms and clinical perspectives

During SARS-CoV-2 infection, an effective immune response provides the first line of defense; however, excessive inflammatory innate immunity and impaired adaptive immunity may harm tissues. Soluble immune mediators are involved in the dynamic interaction of ligands with membrane-bound receptors to...

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Autores principales: Soltani-Zangbar, Mohammad Sadegh, Parhizkar, Forough, Abdollahi, Mojtaba, Shomali, Navid, Aghebati-Maleki, Leili, Shahmohammadi Farid, Sima, Roshangar, Leila, Mahmoodpoor, Ata, Yousefi, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421625/
https://www.ncbi.nlm.nih.gov/pubmed/36038915
http://dx.doi.org/10.1186/s12964-022-00948-7
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author Soltani-Zangbar, Mohammad Sadegh
Parhizkar, Forough
Abdollahi, Mojtaba
Shomali, Navid
Aghebati-Maleki, Leili
Shahmohammadi Farid, Sima
Roshangar, Leila
Mahmoodpoor, Ata
Yousefi, Mehdi
author_facet Soltani-Zangbar, Mohammad Sadegh
Parhizkar, Forough
Abdollahi, Mojtaba
Shomali, Navid
Aghebati-Maleki, Leili
Shahmohammadi Farid, Sima
Roshangar, Leila
Mahmoodpoor, Ata
Yousefi, Mehdi
author_sort Soltani-Zangbar, Mohammad Sadegh
collection PubMed
description During SARS-CoV-2 infection, an effective immune response provides the first line of defense; however, excessive inflammatory innate immunity and impaired adaptive immunity may harm tissues. Soluble immune mediators are involved in the dynamic interaction of ligands with membrane-bound receptors to maintain and restore health after pathological events. In some cases, the dysregulation of their expression can lead to disease pathology. In this literature review, we described current knowledge of the basic features of soluble immune mediators and their dysregulation during SARS-CoV-2 infections and highlighted their contribution to disease severity and mortality. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00948-7.
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spelling pubmed-94216252022-08-30 Immune system-related soluble mediators and COVID-19: basic mechanisms and clinical perspectives Soltani-Zangbar, Mohammad Sadegh Parhizkar, Forough Abdollahi, Mojtaba Shomali, Navid Aghebati-Maleki, Leili Shahmohammadi Farid, Sima Roshangar, Leila Mahmoodpoor, Ata Yousefi, Mehdi Cell Commun Signal Review During SARS-CoV-2 infection, an effective immune response provides the first line of defense; however, excessive inflammatory innate immunity and impaired adaptive immunity may harm tissues. Soluble immune mediators are involved in the dynamic interaction of ligands with membrane-bound receptors to maintain and restore health after pathological events. In some cases, the dysregulation of their expression can lead to disease pathology. In this literature review, we described current knowledge of the basic features of soluble immune mediators and their dysregulation during SARS-CoV-2 infections and highlighted their contribution to disease severity and mortality. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00948-7. BioMed Central 2022-08-29 /pmc/articles/PMC9421625/ /pubmed/36038915 http://dx.doi.org/10.1186/s12964-022-00948-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Soltani-Zangbar, Mohammad Sadegh
Parhizkar, Forough
Abdollahi, Mojtaba
Shomali, Navid
Aghebati-Maleki, Leili
Shahmohammadi Farid, Sima
Roshangar, Leila
Mahmoodpoor, Ata
Yousefi, Mehdi
Immune system-related soluble mediators and COVID-19: basic mechanisms and clinical perspectives
title Immune system-related soluble mediators and COVID-19: basic mechanisms and clinical perspectives
title_full Immune system-related soluble mediators and COVID-19: basic mechanisms and clinical perspectives
title_fullStr Immune system-related soluble mediators and COVID-19: basic mechanisms and clinical perspectives
title_full_unstemmed Immune system-related soluble mediators and COVID-19: basic mechanisms and clinical perspectives
title_short Immune system-related soluble mediators and COVID-19: basic mechanisms and clinical perspectives
title_sort immune system-related soluble mediators and covid-19: basic mechanisms and clinical perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421625/
https://www.ncbi.nlm.nih.gov/pubmed/36038915
http://dx.doi.org/10.1186/s12964-022-00948-7
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