Build–Couple–Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity

[Image: see text] High-throughput screening provides one of the most common ways of finding hit compounds. Lead-like libraries, in particular, provide hits with compatible functional groups and vectors for structural elaboration and physical properties suitable for optimization. Library synthesis ap...

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Detalles Bibliográficos
Autores principales: Uguen, Mélanie, Davison, Gemma, Sprenger, Lukas J., Hunter, James H., Martin, Mathew P., Turberville, Shannon, Watt, Jessica E., Golding, Bernard T., Noble, Martin E. M., Stewart, Hannah L., Waring, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421646/
https://www.ncbi.nlm.nih.gov/pubmed/35943172
http://dx.doi.org/10.1021/acs.jmedchem.2c00897

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