Investigating the Structure–Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists

[Image: see text] G-protein-coupled receptor 84 (GPR84) is a proinflammatory orphan G-protein-coupled receptor implicated in several inflammatory and fibrotic diseases. Several agonist and antagonist ligands have been developed that target GPR84; however, a noncompetitive receptor blocker that was p...

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Detalles Bibliográficos
Autores principales: Mahindra, Amit, Jenkins, Laura, Marsango, Sara, Huggett, Mark, Huggett, Margaret, Robinson, Lindsay, Gillespie, Jonathan, Rajamanickam, Muralikrishnan, Morrison, Angus, McElroy, Stuart, Tikhonova, Irina G., Milligan, Graeme, Jamieson, Andrew G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421653/
https://www.ncbi.nlm.nih.gov/pubmed/35948061
http://dx.doi.org/10.1021/acs.jmedchem.2c00804

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