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Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections
[Image: see text] Filarial diseases, including lymphatic filariasis and onchocerciasis, are considered among the most devastating of all tropical diseases, affecting about 145 million people worldwide. Efforts to control and eliminate onchocerciasis are impeded by a lack of effective treatments that...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421654/ https://www.ncbi.nlm.nih.gov/pubmed/35972896 http://dx.doi.org/10.1021/acs.jmedchem.2c00960 |
| _version_ | 1784777642604494848 |
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| author | Hawryluk, Natalie Robinson, Dale Shen, Yixing Kyne, Graham Bedore, Matthew Menon, Sanjay Canan, Stacie von Geldern, Thomas Townson, Simon Gokool, Suzanne Ehrens, Alexandra Koschel, Marianne Lhermitte-Vallarino, Nathaly Martin, Coralie Hoerauf, Achim Hernandez, Geraldine Dalvie, Deepak Specht, Sabine Hübner, Marc Peter Scandale, Ivan |
| author_facet | Hawryluk, Natalie Robinson, Dale Shen, Yixing Kyne, Graham Bedore, Matthew Menon, Sanjay Canan, Stacie von Geldern, Thomas Townson, Simon Gokool, Suzanne Ehrens, Alexandra Koschel, Marianne Lhermitte-Vallarino, Nathaly Martin, Coralie Hoerauf, Achim Hernandez, Geraldine Dalvie, Deepak Specht, Sabine Hübner, Marc Peter Scandale, Ivan |
| author_sort | Hawryluk, Natalie |
| collection | PubMed |
| description | [Image: see text] Filarial diseases, including lymphatic filariasis and onchocerciasis, are considered among the most devastating of all tropical diseases, affecting about 145 million people worldwide. Efforts to control and eliminate onchocerciasis are impeded by a lack of effective treatments that target the adult filarial stage. Herein, we describe the discovery of a series of substituted di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as novel macrofilaricides for the treatment of human filarial infections. |
| format | Online Article Text |
| id | pubmed-9421654 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | American Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-94216542022-08-30 Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections Hawryluk, Natalie Robinson, Dale Shen, Yixing Kyne, Graham Bedore, Matthew Menon, Sanjay Canan, Stacie von Geldern, Thomas Townson, Simon Gokool, Suzanne Ehrens, Alexandra Koschel, Marianne Lhermitte-Vallarino, Nathaly Martin, Coralie Hoerauf, Achim Hernandez, Geraldine Dalvie, Deepak Specht, Sabine Hübner, Marc Peter Scandale, Ivan J Med Chem [Image: see text] Filarial diseases, including lymphatic filariasis and onchocerciasis, are considered among the most devastating of all tropical diseases, affecting about 145 million people worldwide. Efforts to control and eliminate onchocerciasis are impeded by a lack of effective treatments that target the adult filarial stage. Herein, we describe the discovery of a series of substituted di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as novel macrofilaricides for the treatment of human filarial infections. American Chemical Society 2022-08-16 2022-08-25 /pmc/articles/PMC9421654/ /pubmed/35972896 http://dx.doi.org/10.1021/acs.jmedchem.2c00960 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Hawryluk, Natalie Robinson, Dale Shen, Yixing Kyne, Graham Bedore, Matthew Menon, Sanjay Canan, Stacie von Geldern, Thomas Townson, Simon Gokool, Suzanne Ehrens, Alexandra Koschel, Marianne Lhermitte-Vallarino, Nathaly Martin, Coralie Hoerauf, Achim Hernandez, Geraldine Dalvie, Deepak Specht, Sabine Hübner, Marc Peter Scandale, Ivan Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections |
| title | Discovery of
Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines
as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial
Infections |
| title_full | Discovery of
Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines
as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial
Infections |
| title_fullStr | Discovery of
Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines
as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial
Infections |
| title_full_unstemmed | Discovery of
Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines
as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial
Infections |
| title_short | Discovery of
Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines
as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial
Infections |
| title_sort | discovery of
substituted di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines
as novel macrofilaricidal compounds for the treatment of human filarial
infections |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421654/ https://www.ncbi.nlm.nih.gov/pubmed/35972896 http://dx.doi.org/10.1021/acs.jmedchem.2c00960 |
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