Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections

[Image: see text] Filarial diseases, including lymphatic filariasis and onchocerciasis, are considered among the most devastating of all tropical diseases, affecting about 145 million people worldwide. Efforts to control and eliminate onchocerciasis are impeded by a lack of effective treatments that...

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Detalles Bibliográficos
Autores principales: Hawryluk, Natalie, Robinson, Dale, Shen, Yixing, Kyne, Graham, Bedore, Matthew, Menon, Sanjay, Canan, Stacie, von Geldern, Thomas, Townson, Simon, Gokool, Suzanne, Ehrens, Alexandra, Koschel, Marianne, Lhermitte-Vallarino, Nathaly, Martin, Coralie, Hoerauf, Achim, Hernandez, Geraldine, Dalvie, Deepak, Specht, Sabine, Hübner, Marc Peter, Scandale, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421654/
https://www.ncbi.nlm.nih.gov/pubmed/35972896
http://dx.doi.org/10.1021/acs.jmedchem.2c00960

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