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A Genome-Wide Association Study on Abdominal Adiposity-Related Traits in Adult Korean Men
INTRODUCTION: Although previous genome-wide association studies (GWASs) have identified genetic susceptibility loci for abdominal adiposity, GWASs on Asian samples remain scarce. Therefore, we performed a GWAS for abdominal adipose tissue depots in a Korean population. METHODS: A total of 1,937 Kore...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421669/ https://www.ncbi.nlm.nih.gov/pubmed/35472719 http://dx.doi.org/10.1159/000524670 |
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author | Kim, Hyun-Jin Son, Ho-young Sung, Joohon Yun, Jae Moon Kwon, Hyuktae Cho, Belong Kim, Jong-Il Park, Jin-Ho |
author_facet | Kim, Hyun-Jin Son, Ho-young Sung, Joohon Yun, Jae Moon Kwon, Hyuktae Cho, Belong Kim, Jong-Il Park, Jin-Ho |
author_sort | Kim, Hyun-Jin |
collection | PubMed |
description | INTRODUCTION: Although previous genome-wide association studies (GWASs) have identified genetic susceptibility loci for abdominal adiposity, GWASs on Asian samples remain scarce. Therefore, we performed a GWAS for abdominal adipose tissue depots in a Korean population. METHODS: A total of 1,937 Korean men were included in the study. Areas of abdominal fat were quantified by computed tomography. We performed a GWAS analysis under an additive model, and a replication study was conducted on 480 additional Korean adult men. RESULTS: In the discovery step, we identified a total of 10 single-nucleotide polymorphisms (SNPs) associated with adiposity indicators (p < 1 × 10(−5)). The top SNP, rs1028014, for visceral adipose tissue (VAT) was located in the ZMAT4 gene and remained significant after adjustment for body mass index (BMI). Three additional SNPs were also associated with VAT-adj-BMI and located within the SLC26A10, FAM155A, and COL4A1-COL4A2 genes, respectively. In addition, we identified a SNP (rs4668224) of the MYO3B gene for visceral-to-subcutaneous fat ratio. For subcutaneous adipose tissue and total adipose tissue, two (rs6585735 and rs363527) and three SNPs (rs1487892, rs9357565, and rs1985358) were found, respectively. Overall, eight SNPs were used in the replication study; however, none of the SNPs reached our level of significance for replication (p < 0.0063). Nevertheless, rs4773144 of COL4A1-COL4A2 for VAT-adj-BMI was the most interesting SNP identified in previous GWASs for coronary artery disease (based on the same risk allele “G”), along with functional effects. CONCLUSION: This study suggests for the first time that an SNP (rs4773144) of COL4A1-COL4A2 may contribute to the increase in VAT level, especially in adult Korean men. |
format | Online Article Text |
id | pubmed-9421669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-94216692022-09-23 A Genome-Wide Association Study on Abdominal Adiposity-Related Traits in Adult Korean Men Kim, Hyun-Jin Son, Ho-young Sung, Joohon Yun, Jae Moon Kwon, Hyuktae Cho, Belong Kim, Jong-Il Park, Jin-Ho Obes Facts Research Article INTRODUCTION: Although previous genome-wide association studies (GWASs) have identified genetic susceptibility loci for abdominal adiposity, GWASs on Asian samples remain scarce. Therefore, we performed a GWAS for abdominal adipose tissue depots in a Korean population. METHODS: A total of 1,937 Korean men were included in the study. Areas of abdominal fat were quantified by computed tomography. We performed a GWAS analysis under an additive model, and a replication study was conducted on 480 additional Korean adult men. RESULTS: In the discovery step, we identified a total of 10 single-nucleotide polymorphisms (SNPs) associated with adiposity indicators (p < 1 × 10(−5)). The top SNP, rs1028014, for visceral adipose tissue (VAT) was located in the ZMAT4 gene and remained significant after adjustment for body mass index (BMI). Three additional SNPs were also associated with VAT-adj-BMI and located within the SLC26A10, FAM155A, and COL4A1-COL4A2 genes, respectively. In addition, we identified a SNP (rs4668224) of the MYO3B gene for visceral-to-subcutaneous fat ratio. For subcutaneous adipose tissue and total adipose tissue, two (rs6585735 and rs363527) and three SNPs (rs1487892, rs9357565, and rs1985358) were found, respectively. Overall, eight SNPs were used in the replication study; however, none of the SNPs reached our level of significance for replication (p < 0.0063). Nevertheless, rs4773144 of COL4A1-COL4A2 for VAT-adj-BMI was the most interesting SNP identified in previous GWASs for coronary artery disease (based on the same risk allele “G”), along with functional effects. CONCLUSION: This study suggests for the first time that an SNP (rs4773144) of COL4A1-COL4A2 may contribute to the increase in VAT level, especially in adult Korean men. S. Karger AG 2022-04-26 /pmc/articles/PMC9421669/ /pubmed/35472719 http://dx.doi.org/10.1159/000524670 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. |
spellingShingle | Research Article Kim, Hyun-Jin Son, Ho-young Sung, Joohon Yun, Jae Moon Kwon, Hyuktae Cho, Belong Kim, Jong-Il Park, Jin-Ho A Genome-Wide Association Study on Abdominal Adiposity-Related Traits in Adult Korean Men |
title | A Genome-Wide Association Study on Abdominal Adiposity-Related Traits in Adult Korean Men |
title_full | A Genome-Wide Association Study on Abdominal Adiposity-Related Traits in Adult Korean Men |
title_fullStr | A Genome-Wide Association Study on Abdominal Adiposity-Related Traits in Adult Korean Men |
title_full_unstemmed | A Genome-Wide Association Study on Abdominal Adiposity-Related Traits in Adult Korean Men |
title_short | A Genome-Wide Association Study on Abdominal Adiposity-Related Traits in Adult Korean Men |
title_sort | genome-wide association study on abdominal adiposity-related traits in adult korean men |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421669/ https://www.ncbi.nlm.nih.gov/pubmed/35472719 http://dx.doi.org/10.1159/000524670 |
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