Higher recipient pre‐transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT

The effect of higher FOXP3 mRNA expression by recipient pre‐transplant CD4+ T cells on leukaemia relapse was analysed in a series of 106 patients who received allogeneic haematopoietic stem cell transplantation after myeloablative conditioning with or without antithymocyte globulin (ATG) due to acut...

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Detalles Bibliográficos
Autores principales: Jacobsen, Niels, Frisch, Tina, Keiding, Niels, Heilmann, Carsten, Sengeløv, Henrik, Madsen, Hans O., Dickmeiss, Ebbe, Ryder, Lars P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421961/
https://www.ncbi.nlm.nih.gov/pubmed/36051013
http://dx.doi.org/10.1002/jha2.438
Descripción
Sumario:The effect of higher FOXP3 mRNA expression by recipient pre‐transplant CD4+ T cells on leukaemia relapse was analysed in a series of 106 patients who received allogeneic haematopoietic stem cell transplantation after myeloablative conditioning with or without antithymocyte globulin (ATG) due to acute leukaemia in 1st or 2nd complete remission. FOXP3 mRNA was measured by qPCR in purified CD4+ T cells from blood obtained before conditioning. Higher FOXP3 mRNA expression was associated with an increased relapse risk when conditioning included ATG (n = 43, hazard ratio [HR] 11.0 [2.50–48.4], p = 0.00001). No effect was observed in patients not receiving ATG (HR 0.95 [0.53–1.81]).

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