Higher recipient pre‐transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT

The effect of higher FOXP3 mRNA expression by recipient pre‐transplant CD4+ T cells on leukaemia relapse was analysed in a series of 106 patients who received allogeneic haematopoietic stem cell transplantation after myeloablative conditioning with or without antithymocyte globulin (ATG) due to acut...

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Autores principales: Jacobsen, Niels, Frisch, Tina, Keiding, Niels, Heilmann, Carsten, Sengeløv, Henrik, Madsen, Hans O., Dickmeiss, Ebbe, Ryder, Lars P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421961/
https://www.ncbi.nlm.nih.gov/pubmed/36051013
http://dx.doi.org/10.1002/jha2.438
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author Jacobsen, Niels
Frisch, Tina
Keiding, Niels
Heilmann, Carsten
Sengeløv, Henrik
Madsen, Hans O.
Dickmeiss, Ebbe
Ryder, Lars P.
author_facet Jacobsen, Niels
Frisch, Tina
Keiding, Niels
Heilmann, Carsten
Sengeløv, Henrik
Madsen, Hans O.
Dickmeiss, Ebbe
Ryder, Lars P.
author_sort Jacobsen, Niels
collection PubMed
description The effect of higher FOXP3 mRNA expression by recipient pre‐transplant CD4+ T cells on leukaemia relapse was analysed in a series of 106 patients who received allogeneic haematopoietic stem cell transplantation after myeloablative conditioning with or without antithymocyte globulin (ATG) due to acute leukaemia in 1st or 2nd complete remission. FOXP3 mRNA was measured by qPCR in purified CD4+ T cells from blood obtained before conditioning. Higher FOXP3 mRNA expression was associated with an increased relapse risk when conditioning included ATG (n = 43, hazard ratio [HR] 11.0 [2.50–48.4], p = 0.00001). No effect was observed in patients not receiving ATG (HR 0.95 [0.53–1.81]).
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spelling pubmed-94219612022-08-31 Higher recipient pre‐transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT Jacobsen, Niels Frisch, Tina Keiding, Niels Heilmann, Carsten Sengeløv, Henrik Madsen, Hans O. Dickmeiss, Ebbe Ryder, Lars P. EJHaem Short Reports The effect of higher FOXP3 mRNA expression by recipient pre‐transplant CD4+ T cells on leukaemia relapse was analysed in a series of 106 patients who received allogeneic haematopoietic stem cell transplantation after myeloablative conditioning with or without antithymocyte globulin (ATG) due to acute leukaemia in 1st or 2nd complete remission. FOXP3 mRNA was measured by qPCR in purified CD4+ T cells from blood obtained before conditioning. Higher FOXP3 mRNA expression was associated with an increased relapse risk when conditioning included ATG (n = 43, hazard ratio [HR] 11.0 [2.50–48.4], p = 0.00001). No effect was observed in patients not receiving ATG (HR 0.95 [0.53–1.81]). John Wiley and Sons Inc. 2022-04-30 /pmc/articles/PMC9421961/ /pubmed/36051013 http://dx.doi.org/10.1002/jha2.438 Text en © 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Jacobsen, Niels
Frisch, Tina
Keiding, Niels
Heilmann, Carsten
Sengeløv, Henrik
Madsen, Hans O.
Dickmeiss, Ebbe
Ryder, Lars P.
Higher recipient pre‐transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT
title Higher recipient pre‐transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT
title_full Higher recipient pre‐transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT
title_fullStr Higher recipient pre‐transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT
title_full_unstemmed Higher recipient pre‐transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT
title_short Higher recipient pre‐transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT
title_sort higher recipient pre‐transplant foxp3 mrna expression is associated with acute leukaemia relapse after hsct
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421961/
https://www.ncbi.nlm.nih.gov/pubmed/36051013
http://dx.doi.org/10.1002/jha2.438
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