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Long‐term efficacy and safety of programmed death‐1 (PD‐1) antibody alone in relapsed/refractory human immunodeficiency virus‐associated Hodgkin lymphoma

We report a young patient initially diagnosed with human immunodeficiency virus (HIV)‐associated Hodgkin lymphoma (HL), and received six cycles of ABVD chemotherapy regimens and involvement field irradiation therapy. However, the disease progressed after two months later, and then received second li...

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Autores principales: Wang, Chaoyu, Zhou, Fanlin, Zhang, Lingqian, Liu, Tingting, Nan, Yingyu, Liu, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421984/
https://www.ncbi.nlm.nih.gov/pubmed/36051083
http://dx.doi.org/10.1002/jha2.448
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author Wang, Chaoyu
Zhou, Fanlin
Zhang, Lingqian
Liu, Tingting
Nan, Yingyu
Liu, Yao
author_facet Wang, Chaoyu
Zhou, Fanlin
Zhang, Lingqian
Liu, Tingting
Nan, Yingyu
Liu, Yao
author_sort Wang, Chaoyu
collection PubMed
description We report a young patient initially diagnosed with human immunodeficiency virus (HIV)‐associated Hodgkin lymphoma (HL), and received six cycles of ABVD chemotherapy regimens and involvement field irradiation therapy. However, the disease progressed after two months later, and then received second line GDP regimen. Unfortunately, after five cycles of GDP, the patient progression disease (PD) again. The patient was then offered sintilimab alone. After 8 cycles, the patient received complete response (CR) and no 3/4 grade toxicity. Currently, at a follow‐up period of four years, he is still alive with CR and no lymphoma‐related symptoms. This case demonstrates the feasibility of sintilimab antibody in relapsed/refractory HIV‐associated Hodgkin lymphoma.
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spelling pubmed-94219842022-08-31 Long‐term efficacy and safety of programmed death‐1 (PD‐1) antibody alone in relapsed/refractory human immunodeficiency virus‐associated Hodgkin lymphoma Wang, Chaoyu Zhou, Fanlin Zhang, Lingqian Liu, Tingting Nan, Yingyu Liu, Yao EJHaem Short Reports We report a young patient initially diagnosed with human immunodeficiency virus (HIV)‐associated Hodgkin lymphoma (HL), and received six cycles of ABVD chemotherapy regimens and involvement field irradiation therapy. However, the disease progressed after two months later, and then received second line GDP regimen. Unfortunately, after five cycles of GDP, the patient progression disease (PD) again. The patient was then offered sintilimab alone. After 8 cycles, the patient received complete response (CR) and no 3/4 grade toxicity. Currently, at a follow‐up period of four years, he is still alive with CR and no lymphoma‐related symptoms. This case demonstrates the feasibility of sintilimab antibody in relapsed/refractory HIV‐associated Hodgkin lymphoma. John Wiley and Sons Inc. 2022-05-04 /pmc/articles/PMC9421984/ /pubmed/36051083 http://dx.doi.org/10.1002/jha2.448 Text en © 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Wang, Chaoyu
Zhou, Fanlin
Zhang, Lingqian
Liu, Tingting
Nan, Yingyu
Liu, Yao
Long‐term efficacy and safety of programmed death‐1 (PD‐1) antibody alone in relapsed/refractory human immunodeficiency virus‐associated Hodgkin lymphoma
title Long‐term efficacy and safety of programmed death‐1 (PD‐1) antibody alone in relapsed/refractory human immunodeficiency virus‐associated Hodgkin lymphoma
title_full Long‐term efficacy and safety of programmed death‐1 (PD‐1) antibody alone in relapsed/refractory human immunodeficiency virus‐associated Hodgkin lymphoma
title_fullStr Long‐term efficacy and safety of programmed death‐1 (PD‐1) antibody alone in relapsed/refractory human immunodeficiency virus‐associated Hodgkin lymphoma
title_full_unstemmed Long‐term efficacy and safety of programmed death‐1 (PD‐1) antibody alone in relapsed/refractory human immunodeficiency virus‐associated Hodgkin lymphoma
title_short Long‐term efficacy and safety of programmed death‐1 (PD‐1) antibody alone in relapsed/refractory human immunodeficiency virus‐associated Hodgkin lymphoma
title_sort long‐term efficacy and safety of programmed death‐1 (pd‐1) antibody alone in relapsed/refractory human immunodeficiency virus‐associated hodgkin lymphoma
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421984/
https://www.ncbi.nlm.nih.gov/pubmed/36051083
http://dx.doi.org/10.1002/jha2.448
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