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Inactivating BTK mutations in large B‐cell lymphoma in a real‐world cohort: Strong correlation with BCL2 translocation

Inactivating mutations in Bruton's tyrosine kinase (BTK) in patients with follicular lymphoma (FL) have recently been reported. These mutations were found in BTK inhibitor‐treatment naïve patients. Here, we report the BTK mutation status in a real‐world cohort of patients with non‐Hodgkin lymph...

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Autores principales: Schejbel, Lone, Breinholt, Marie Fredslund, Gang, Anne Ortved, Nielsen, Torsten Holm, Pedersen, Lars Møller, Høgdall, Estrid, Nørgaard, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421985/
https://www.ncbi.nlm.nih.gov/pubmed/36051027
http://dx.doi.org/10.1002/jha2.489
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author Schejbel, Lone
Breinholt, Marie Fredslund
Gang, Anne Ortved
Nielsen, Torsten Holm
Pedersen, Lars Møller
Høgdall, Estrid
Nørgaard, Peter
author_facet Schejbel, Lone
Breinholt, Marie Fredslund
Gang, Anne Ortved
Nielsen, Torsten Holm
Pedersen, Lars Møller
Høgdall, Estrid
Nørgaard, Peter
author_sort Schejbel, Lone
collection PubMed
description Inactivating mutations in Bruton's tyrosine kinase (BTK) in patients with follicular lymphoma (FL) have recently been reported. These mutations were found in BTK inhibitor‐treatment naïve patients. Here, we report the BTK mutation status in a real‐world cohort of patients with non‐Hodgkin lymphoma. We found primary BTK mutations in 7.7% of patients with large B‐cell lymphoma (LBCL) and in 14.1% of patients with FL. All patients with BTK‐mutated LBCL were BCL2 translocation positive, and the correlation between BCL2 translocation and BTK mutation persisted even when patients with known transformation from FL were excluded.
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spelling pubmed-94219852022-08-31 Inactivating BTK mutations in large B‐cell lymphoma in a real‐world cohort: Strong correlation with BCL2 translocation Schejbel, Lone Breinholt, Marie Fredslund Gang, Anne Ortved Nielsen, Torsten Holm Pedersen, Lars Møller Høgdall, Estrid Nørgaard, Peter EJHaem Short Reports Inactivating mutations in Bruton's tyrosine kinase (BTK) in patients with follicular lymphoma (FL) have recently been reported. These mutations were found in BTK inhibitor‐treatment naïve patients. Here, we report the BTK mutation status in a real‐world cohort of patients with non‐Hodgkin lymphoma. We found primary BTK mutations in 7.7% of patients with large B‐cell lymphoma (LBCL) and in 14.1% of patients with FL. All patients with BTK‐mutated LBCL were BCL2 translocation positive, and the correlation between BCL2 translocation and BTK mutation persisted even when patients with known transformation from FL were excluded. John Wiley and Sons Inc. 2022-06-24 /pmc/articles/PMC9421985/ /pubmed/36051027 http://dx.doi.org/10.1002/jha2.489 Text en © 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Schejbel, Lone
Breinholt, Marie Fredslund
Gang, Anne Ortved
Nielsen, Torsten Holm
Pedersen, Lars Møller
Høgdall, Estrid
Nørgaard, Peter
Inactivating BTK mutations in large B‐cell lymphoma in a real‐world cohort: Strong correlation with BCL2 translocation
title Inactivating BTK mutations in large B‐cell lymphoma in a real‐world cohort: Strong correlation with BCL2 translocation
title_full Inactivating BTK mutations in large B‐cell lymphoma in a real‐world cohort: Strong correlation with BCL2 translocation
title_fullStr Inactivating BTK mutations in large B‐cell lymphoma in a real‐world cohort: Strong correlation with BCL2 translocation
title_full_unstemmed Inactivating BTK mutations in large B‐cell lymphoma in a real‐world cohort: Strong correlation with BCL2 translocation
title_short Inactivating BTK mutations in large B‐cell lymphoma in a real‐world cohort: Strong correlation with BCL2 translocation
title_sort inactivating btk mutations in large b‐cell lymphoma in a real‐world cohort: strong correlation with bcl2 translocation
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421985/
https://www.ncbi.nlm.nih.gov/pubmed/36051027
http://dx.doi.org/10.1002/jha2.489
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