Developmental disorders in children born to women with sickle cell disease: A report from the Boston Birth Cohort

Children exposed to maternal sickle cell disease (SCD) have many theoretical risks for developmental disorders, but little is known about long‐term outcomes for these children. We used the Boston Birth Cohort to compare developmental outcomes between children exposed to maternal SCD and matched, une...

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Autores principales: Brucato, Martha, Lance, Eboni, Lanzkron, Sophie, Wang, Xiaobin, Pecker, Lydia H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421989/
https://www.ncbi.nlm.nih.gov/pubmed/36051016
http://dx.doi.org/10.1002/jha2.478
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author Brucato, Martha
Lance, Eboni
Lanzkron, Sophie
Wang, Xiaobin
Pecker, Lydia H.
author_facet Brucato, Martha
Lance, Eboni
Lanzkron, Sophie
Wang, Xiaobin
Pecker, Lydia H.
author_sort Brucato, Martha
collection PubMed
description Children exposed to maternal sickle cell disease (SCD) have many theoretical risks for developmental disorders, but little is known about long‐term outcomes for these children. We used the Boston Birth Cohort to compare developmental outcomes between children exposed to maternal SCD and matched, unexposed controls. Children with exposure to maternal SCD had increased risk of attention deficit hyperactivity disorder (OR 5.12, 95% CI 1.36–19.19, p = 0.02) and obesity (OR 2.74, 95% CI 1.10–6.87, p = 0.03). In utero and/or environmental exposures may help explain these findings. Further studies of outcomes of children born to women with SCD are needed.
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spelling pubmed-94219892022-08-31 Developmental disorders in children born to women with sickle cell disease: A report from the Boston Birth Cohort Brucato, Martha Lance, Eboni Lanzkron, Sophie Wang, Xiaobin Pecker, Lydia H. EJHaem Short Reports Children exposed to maternal sickle cell disease (SCD) have many theoretical risks for developmental disorders, but little is known about long‐term outcomes for these children. We used the Boston Birth Cohort to compare developmental outcomes between children exposed to maternal SCD and matched, unexposed controls. Children with exposure to maternal SCD had increased risk of attention deficit hyperactivity disorder (OR 5.12, 95% CI 1.36–19.19, p = 0.02) and obesity (OR 2.74, 95% CI 1.10–6.87, p = 0.03). In utero and/or environmental exposures may help explain these findings. Further studies of outcomes of children born to women with SCD are needed. John Wiley and Sons Inc. 2022-06-08 /pmc/articles/PMC9421989/ /pubmed/36051016 http://dx.doi.org/10.1002/jha2.478 Text en © 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Brucato, Martha
Lance, Eboni
Lanzkron, Sophie
Wang, Xiaobin
Pecker, Lydia H.
Developmental disorders in children born to women with sickle cell disease: A report from the Boston Birth Cohort
title Developmental disorders in children born to women with sickle cell disease: A report from the Boston Birth Cohort
title_full Developmental disorders in children born to women with sickle cell disease: A report from the Boston Birth Cohort
title_fullStr Developmental disorders in children born to women with sickle cell disease: A report from the Boston Birth Cohort
title_full_unstemmed Developmental disorders in children born to women with sickle cell disease: A report from the Boston Birth Cohort
title_short Developmental disorders in children born to women with sickle cell disease: A report from the Boston Birth Cohort
title_sort developmental disorders in children born to women with sickle cell disease: a report from the boston birth cohort
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421989/
https://www.ncbi.nlm.nih.gov/pubmed/36051016
http://dx.doi.org/10.1002/jha2.478
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