Blood‐circulating EV‐miRNAs, serum TARC, and quantitative FDG‐PET features in classical Hodgkin lymphoma

Blood‐based biomarkers are gaining interest for response evaluation in classical Hodgkin lymphoma (cHL). However, it is unknown how blood‐based biomarkers relate to quantitative (18)F‐FDG‐PET features. We correlated extracellular vesicle‐associated miRNAs (EV‐miRNA), serum TARC, and complete blood c...

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Detalles Bibliográficos
Autores principales: Drees, Esther E. E., Driessen, Julia, Zwezerijnen, Gerben J. C., Verkuijlen, Sandra A. W. M., Eertink, Jakoba J., van Eijndhoven, Monique A. J., Groenewegen, Nils J., Vallés‐Martí, Andrea, de Jong, Daphne, Boellaard, Ronald, de Vet, Henrica C. W., Pegtel, Dirk M., Zijlstra, Josée M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422001/
https://www.ncbi.nlm.nih.gov/pubmed/36051072
http://dx.doi.org/10.1002/jha2.432
Descripción
Sumario:Blood‐based biomarkers are gaining interest for response evaluation in classical Hodgkin lymphoma (cHL). However, it is unknown how blood‐based biomarkers relate to quantitative (18)F‐FDG‐PET features. We correlated extracellular vesicle‐associated miRNAs (EV‐miRNA), serum TARC, and complete blood count (CBC) with PET features (e.g., metabolic tumor volume [MTV], dissemination and intensity features) in 30 cHL patients at baseline. EV‐miR127‐3p, EV‐miR24‐3p, sTARC, and several CBC parameters showed weak to strong correlations with MTV and dissemination features, but not with intensity features. Two other EV‐miRNAs only showed weak correlations with PET features. Therefore, blood‐based biomarkers may be complementary to PET features, which warrants further exploration of combining these biomarkers in prognostic models.

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