Low mitochondrial DNA copy number induces chemotherapy resistance via epithelial-mesenchymal transition by DNA methylation in esophageal squamous cancer cells

BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is one of the most severe cancers and is characterized by chemotherapy resistance and poor prognosis associated with epithelial-mesenchymal transition (EMT). In a previous study, a low mitochondrial DNA (mtDNA) copy number was associated with poo...

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Detalles Bibliográficos
Autores principales: Kubo, Yuto, Tanaka, Koji, Masuike, Yasunori, Takahashi, Tsuyoshi, Yamashita, Kotaro, Makino, Tomoki, Saito, Takuro, Yamamoto, Kazuyoshi, Tsujimoto, Tomoyuki, Harino, Takashi, Kurokawa, Yukinori, Yamasaki, Makoto, Nakajima, Kiyokazu, Eguchi, Hidetoshi, Doki, Yuichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422107/
https://www.ncbi.nlm.nih.gov/pubmed/36038893
http://dx.doi.org/10.1186/s12967-022-03594-2

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