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Influenza vaccination and dementia risk; an unanticipated benefit?

Alzheimer's disease (AD) characterized by cognitive decline and dementia has evolved into source of extreme concern globally, often associated with functional dependence and financial instability before progressing to complete degeneration of neural and motor skills. Despite multiple interventi...

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Detalles Bibliográficos
Autores principales: Ali, Eman, Shaikh, Asim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422174/
https://www.ncbi.nlm.nih.gov/pubmed/36045777
http://dx.doi.org/10.1016/j.amsu.2022.104187
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author Ali, Eman
Shaikh, Asim
author_facet Ali, Eman
Shaikh, Asim
author_sort Ali, Eman
collection PubMed
description Alzheimer's disease (AD) characterized by cognitive decline and dementia has evolved into source of extreme concern globally, often associated with functional dependence and financial instability before progressing to complete degeneration of neural and motor skills. Despite multiple interventions being available, only few have been able to show clinical efficacy, others not meeting satisfactory efficacy endpoints as more options are being explored. According to various studies, influenza vaccines have shown clinical evidence in being effective against reduction in dementia risk. Multiple large-scale cohort studies are being conducted to test the effectiveness of vaccinations against dementia. Some of them have shown significant results, establishing a statistically significant relationship between vaccinations and a reduction in symptomatology in already diagnosed dementia patients. These vaccines offer lower-cost, low-risk mechanism of prevention of dementia with better outcomes than pre-existing vaccines. However, there is a need of more large-scale retrospective studies and randomized trials, with longer follow-ups, to be conducted to assess the safety and consistent efficacy of this strategy.
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spelling pubmed-94221742022-08-30 Influenza vaccination and dementia risk; an unanticipated benefit? Ali, Eman Shaikh, Asim Ann Med Surg (Lond) Short Communication Alzheimer's disease (AD) characterized by cognitive decline and dementia has evolved into source of extreme concern globally, often associated with functional dependence and financial instability before progressing to complete degeneration of neural and motor skills. Despite multiple interventions being available, only few have been able to show clinical efficacy, others not meeting satisfactory efficacy endpoints as more options are being explored. According to various studies, influenza vaccines have shown clinical evidence in being effective against reduction in dementia risk. Multiple large-scale cohort studies are being conducted to test the effectiveness of vaccinations against dementia. Some of them have shown significant results, establishing a statistically significant relationship between vaccinations and a reduction in symptomatology in already diagnosed dementia patients. These vaccines offer lower-cost, low-risk mechanism of prevention of dementia with better outcomes than pre-existing vaccines. However, there is a need of more large-scale retrospective studies and randomized trials, with longer follow-ups, to be conducted to assess the safety and consistent efficacy of this strategy. Elsevier 2022-07-19 /pmc/articles/PMC9422174/ /pubmed/36045777 http://dx.doi.org/10.1016/j.amsu.2022.104187 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Ali, Eman
Shaikh, Asim
Influenza vaccination and dementia risk; an unanticipated benefit?
title Influenza vaccination and dementia risk; an unanticipated benefit?
title_full Influenza vaccination and dementia risk; an unanticipated benefit?
title_fullStr Influenza vaccination and dementia risk; an unanticipated benefit?
title_full_unstemmed Influenza vaccination and dementia risk; an unanticipated benefit?
title_short Influenza vaccination and dementia risk; an unanticipated benefit?
title_sort influenza vaccination and dementia risk; an unanticipated benefit?
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422174/
https://www.ncbi.nlm.nih.gov/pubmed/36045777
http://dx.doi.org/10.1016/j.amsu.2022.104187
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