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Multiple primary squamous cell carcinomas of the oral cavity: A cross-sectional study in vietnam

BACKGROUND: Multiple primary squamous cell carcinomas (MPSCs) of the oral cavity are very uncommon in clinical practice. This study describes the clinical features, imaging, and treatment characteristics of the oral cavity with MPSCs at the same time of diagnosis in our center. Besides, we review th...

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Autores principales: Nguyen Van, Dang, Le Van, Quang, Nguyen Thi Thu, Nhung, Bui Van, Giang, Ta Van, To
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422213/
https://www.ncbi.nlm.nih.gov/pubmed/36045814
http://dx.doi.org/10.1016/j.amsu.2022.104224
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author Nguyen Van, Dang
Le Van, Quang
Nguyen Thi Thu, Nhung
Bui Van, Giang
Ta Van, To
author_facet Nguyen Van, Dang
Le Van, Quang
Nguyen Thi Thu, Nhung
Bui Van, Giang
Ta Van, To
author_sort Nguyen Van, Dang
collection PubMed
description BACKGROUND: Multiple primary squamous cell carcinomas (MPSCs) of the oral cavity are very uncommon in clinical practice. This study describes the clinical features, imaging, and treatment characteristics of the oral cavity with MPSCs at the same time of diagnosis in our center. Besides, we review the literature and prior studies on MPSCs. STUDY DESIGN: A retrospective, descriptive study from January 2019 to December 2021 was conducted on seven patients with MPSCs of the oral cavity at the time of their first diagnosis. Evaluation of the patient's characteristics, the treatment plan, the response to treatment, and the overall survival (OS). RESULTS: Seven male patients ranging in age from 43 to 70 years (Mean: 53.5). Positron Emission Tomography/Computed Tomography (PET/CT) revealed a significantly increased standardized uptake value (SUV) in the index tumor (SUVi = 15.76 ± 1.96). The index tumor is often staged T3, T4; whereas the synchronous tumor is typically staged T1, T2. All patients had concurrent chemoradiotherapy (CCRT) and achieved a partial response in all cases. Mean OS was 14.71 ± 11.85 months. CONCLUSIONS: MPSCs of the oral cavity at the time of diagnosis are uncommon and associated with a poor prognosis for patients. Comprehensive clinical examination, combined imaging diagnostics, with PET/CT being critical for detecting the second lesion, particularly in patients with an advanced index tumor.
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spelling pubmed-94222132022-08-30 Multiple primary squamous cell carcinomas of the oral cavity: A cross-sectional study in vietnam Nguyen Van, Dang Le Van, Quang Nguyen Thi Thu, Nhung Bui Van, Giang Ta Van, To Ann Med Surg (Lond) Cross-sectional Study BACKGROUND: Multiple primary squamous cell carcinomas (MPSCs) of the oral cavity are very uncommon in clinical practice. This study describes the clinical features, imaging, and treatment characteristics of the oral cavity with MPSCs at the same time of diagnosis in our center. Besides, we review the literature and prior studies on MPSCs. STUDY DESIGN: A retrospective, descriptive study from January 2019 to December 2021 was conducted on seven patients with MPSCs of the oral cavity at the time of their first diagnosis. Evaluation of the patient's characteristics, the treatment plan, the response to treatment, and the overall survival (OS). RESULTS: Seven male patients ranging in age from 43 to 70 years (Mean: 53.5). Positron Emission Tomography/Computed Tomography (PET/CT) revealed a significantly increased standardized uptake value (SUV) in the index tumor (SUVi = 15.76 ± 1.96). The index tumor is often staged T3, T4; whereas the synchronous tumor is typically staged T1, T2. All patients had concurrent chemoradiotherapy (CCRT) and achieved a partial response in all cases. Mean OS was 14.71 ± 11.85 months. CONCLUSIONS: MPSCs of the oral cavity at the time of diagnosis are uncommon and associated with a poor prognosis for patients. Comprehensive clinical examination, combined imaging diagnostics, with PET/CT being critical for detecting the second lesion, particularly in patients with an advanced index tumor. Elsevier 2022-08-06 /pmc/articles/PMC9422213/ /pubmed/36045814 http://dx.doi.org/10.1016/j.amsu.2022.104224 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Cross-sectional Study
Nguyen Van, Dang
Le Van, Quang
Nguyen Thi Thu, Nhung
Bui Van, Giang
Ta Van, To
Multiple primary squamous cell carcinomas of the oral cavity: A cross-sectional study in vietnam
title Multiple primary squamous cell carcinomas of the oral cavity: A cross-sectional study in vietnam
title_full Multiple primary squamous cell carcinomas of the oral cavity: A cross-sectional study in vietnam
title_fullStr Multiple primary squamous cell carcinomas of the oral cavity: A cross-sectional study in vietnam
title_full_unstemmed Multiple primary squamous cell carcinomas of the oral cavity: A cross-sectional study in vietnam
title_short Multiple primary squamous cell carcinomas of the oral cavity: A cross-sectional study in vietnam
title_sort multiple primary squamous cell carcinomas of the oral cavity: a cross-sectional study in vietnam
topic Cross-sectional Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422213/
https://www.ncbi.nlm.nih.gov/pubmed/36045814
http://dx.doi.org/10.1016/j.amsu.2022.104224
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