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Increased neutrophil lymphocyte ratio and platelet lymphocyte ratio in malignant parotid tumors()
INTRODUCTION: Recently it has been reported that a high preoperative neutrophil–lymphocyte ratio and platelet–lymphocyte ratio may be related to increased recurrence risk, tumor aggressiveness, and worsened prognosis in various malignancies. OBJECTIVE: The objective of this research is to explore wh...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422377/ https://www.ncbi.nlm.nih.gov/pubmed/31122885 http://dx.doi.org/10.1016/j.bjorl.2019.02.009 |
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author | Kuzucu, İhsan Güler, İsmail Kum, Rauf Oğuzhan Baklacı, Deniz Özcan, Müge |
author_facet | Kuzucu, İhsan Güler, İsmail Kum, Rauf Oğuzhan Baklacı, Deniz Özcan, Müge |
author_sort | Kuzucu, İhsan |
collection | PubMed |
description | INTRODUCTION: Recently it has been reported that a high preoperative neutrophil–lymphocyte ratio and platelet–lymphocyte ratio may be related to increased recurrence risk, tumor aggressiveness, and worsened prognosis in various malignancies. OBJECTIVE: The objective of this research is to explore whether neutrophil–lymphocyte ratio and platelet–lymphocyte ratio in parotid tumors may or may not be used as a cancer marker. METHODS: This retrospective research has been conducted on a total of 228 patients consisting of 83 healthy persons and 145 patients with a mass in the parotid gland, who applied to a tertiary referral center and underwent surgery. Patients have been divided into two groups by their histopathological findings as malignant or benign parotid tumor. A third group consisting of healthy people has been defined as the control group. Also the malignant parotid tumor group has been divided into two subgroups as early stage and advanced stage. The groups have been compared in terms of neutrophil–lymphocyte ratio, platelet–lymphocyte ratio and other laboratory data. RESULTS: The average neutrophil–lymphocyte ratio values of malignant parotid tumor, benign parotid tumor, healthy control groups were 2.51, 2.01, 1.79 respectively and the difference was statistically significant (p < 0.001). There was no significant difference between advanced stage and early stage parotid tumor groups in terms of average neutrophil–lymphocyte ratio value (p = 0.782). In dual comparisons, the platelet–lymphocyte ratio value of patients in the malignant group was found out to be statistically significantly higher than that of benign and control groups (p < 0.001 and p = 0.001 respectively). CONCLUSION: To the best of our knowledge our research is the first in the medical literature comparing neutrophil–lymphocyte ratio and platelet–lymphocyte ratio in patients with parotid tumor. neutrophil–lymphocyte ratio and platelet–lymphocyte ratio can serve as cost-effective, repeatable, easily accessible, and helpful inflammatory markers in order to distinguish patients with malignant parotid tumor from healthy people. |
format | Online Article Text |
id | pubmed-9422377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94223772022-08-31 Increased neutrophil lymphocyte ratio and platelet lymphocyte ratio in malignant parotid tumors() Kuzucu, İhsan Güler, İsmail Kum, Rauf Oğuzhan Baklacı, Deniz Özcan, Müge Braz J Otorhinolaryngol Original Article INTRODUCTION: Recently it has been reported that a high preoperative neutrophil–lymphocyte ratio and platelet–lymphocyte ratio may be related to increased recurrence risk, tumor aggressiveness, and worsened prognosis in various malignancies. OBJECTIVE: The objective of this research is to explore whether neutrophil–lymphocyte ratio and platelet–lymphocyte ratio in parotid tumors may or may not be used as a cancer marker. METHODS: This retrospective research has been conducted on a total of 228 patients consisting of 83 healthy persons and 145 patients with a mass in the parotid gland, who applied to a tertiary referral center and underwent surgery. Patients have been divided into two groups by their histopathological findings as malignant or benign parotid tumor. A third group consisting of healthy people has been defined as the control group. Also the malignant parotid tumor group has been divided into two subgroups as early stage and advanced stage. The groups have been compared in terms of neutrophil–lymphocyte ratio, platelet–lymphocyte ratio and other laboratory data. RESULTS: The average neutrophil–lymphocyte ratio values of malignant parotid tumor, benign parotid tumor, healthy control groups were 2.51, 2.01, 1.79 respectively and the difference was statistically significant (p < 0.001). There was no significant difference between advanced stage and early stage parotid tumor groups in terms of average neutrophil–lymphocyte ratio value (p = 0.782). In dual comparisons, the platelet–lymphocyte ratio value of patients in the malignant group was found out to be statistically significantly higher than that of benign and control groups (p < 0.001 and p = 0.001 respectively). CONCLUSION: To the best of our knowledge our research is the first in the medical literature comparing neutrophil–lymphocyte ratio and platelet–lymphocyte ratio in patients with parotid tumor. neutrophil–lymphocyte ratio and platelet–lymphocyte ratio can serve as cost-effective, repeatable, easily accessible, and helpful inflammatory markers in order to distinguish patients with malignant parotid tumor from healthy people. Elsevier 2019-04-23 /pmc/articles/PMC9422377/ /pubmed/31122885 http://dx.doi.org/10.1016/j.bjorl.2019.02.009 Text en © 2019 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Article Kuzucu, İhsan Güler, İsmail Kum, Rauf Oğuzhan Baklacı, Deniz Özcan, Müge Increased neutrophil lymphocyte ratio and platelet lymphocyte ratio in malignant parotid tumors() |
title | Increased neutrophil lymphocyte ratio and platelet lymphocyte ratio in malignant parotid tumors() |
title_full | Increased neutrophil lymphocyte ratio and platelet lymphocyte ratio in malignant parotid tumors() |
title_fullStr | Increased neutrophil lymphocyte ratio and platelet lymphocyte ratio in malignant parotid tumors() |
title_full_unstemmed | Increased neutrophil lymphocyte ratio and platelet lymphocyte ratio in malignant parotid tumors() |
title_short | Increased neutrophil lymphocyte ratio and platelet lymphocyte ratio in malignant parotid tumors() |
title_sort | increased neutrophil lymphocyte ratio and platelet lymphocyte ratio in malignant parotid tumors() |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422377/ https://www.ncbi.nlm.nih.gov/pubmed/31122885 http://dx.doi.org/10.1016/j.bjorl.2019.02.009 |
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