Cargando…

High PI3K/mTOR and low MAPK/JNK activity results in decreased apoptosis and autophagy in nasal polyposis

INTRODUCTION: Nasal polyposis is a progressive inflammatory disease that reduces the quality of life. The role of apoptotic and autophagic pathways in nasal polyposis pathogenesis is not yet clearly known. OBJECTIVE: In this study we aimed to investigate apoptotic (MAPK/JNK), anti-apoptotic (PI3K/mT...

Descripción completa

Detalles Bibliográficos
Autores principales:	Simsek, Fatma, Eren, Erdem, Bahceci, Selen, Aladag, Ibrahim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422555/ https://www.ncbi.nlm.nih.gov/pubmed/32001208 http://dx.doi.org/10.1016/j.bjorl.2019.12.005

Ejemplares similares

Decreased Expression of FOXP3 in Nasal Polyposis
por: Roongrotwattanasiri, Kannika, et al.
Publicado: (2012)

Apatinib induces apoptosis and autophagy via the PI3K/AKT/mTOR and MAPK/ERK signaling pathways in neuroblastoma
por: Yu, Xiying, et al.
Publicado: (2020)

Effect of PI3K/Akt/mTOR signaling pathway on JNK3 in Parkinsonian rats
por: Chen, Ying, et al.
Publicado: (2019)

Zearalenone Induces Apoptosis and Cytoprotective Autophagy in Chicken Granulosa Cells by PI3K-AKT-mTOR and MAPK Signaling Pathways
por: Zhu, Yifeng, et al.
Publicado: (2021)

mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)

Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
por: Liu, Xihong, et al.
Publicado: (2019)

The Roles of Autophagy, Mitophagy, and the Akt/mTOR Pathway in the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps
por: Wang, Chen, et al.
Publicado: (2022)

mTOR inhibition suppresses Myc-driven polyposis by inducing immunogenic cell death
por: Leibowitz, Brian J., et al.
Publicado: (2023)

Rhinosinusitis with nasal polyposis
por: Sharma, S.C.
Publicado: (2018)

mTOR Pathways in Cancer and Autophagy
por: Paquette, Mathieu, et al.
Publicado: (2018)

Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion
por: Shanware, Naval P., et al.
Publicado: (2014)

Correction to: Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
por: Liu, Xihong, et al.
Publicado: (2019)

Simultaneous perturbation of the MAPK and the PI3K/mTOR pathways does not lead to increased radiosensitization
por: Kuger, Sebastian, et al.
Publicado: (2015)

Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer
por: Siegfried, Zahava, et al.
Publicado: (2013)

The Roles of PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Pheochromocytomas
por: Du, Juan, et al.
Publicado: (2016)

Synergistic targeting of the PI3K/mTOR and MAPK/ERK pathways in Merkel cell carcinoma
por: Temblador, Arturo, et al.
Publicado: (2022)

MAPK/JNK signalling: a potential autophagy regulation pathway
por: Zhou, Yuan-Yuan, et al.
Publicado: (2015)

Platycodin-D Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK Signaling Pathways
por: Zhao, Ruolin, et al.
Publicado: (2015)

Ormeloxifene-induced unfolded protein response contributes to autophagy-associated apoptosis via disruption of Akt/mTOR and activation of JNK
por: Bhattacharjee, Arindam, et al.
Publicado: (2018)

Triptolide Induces Glioma Cell Autophagy and Apoptosis via Upregulating the ROS/JNK and Downregulating the Akt/mTOR Signaling Pathways
por: Liu, Xihong, et al.
Publicado: (2019)

The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling
por: Shorning, Boris Y., et al.
Publicado: (2020)

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway
por: Zheng, Xiangjin, et al.
Publicado: (2021)

The mTOR–Autophagy Axis and the Control of Metabolism
por: Deleyto-Seldas, Nerea, et al.
Publicado: (2021)

A review of nasal polyposis
por: Newton, Jonathan Ray, et al.
Publicado: (2008)

mTOR and MAPK: from localized translation control to epilepsy
por: Pernice, Helena F., et al.
Publicado: (2016)

Gartanin induces cell cycle arrest and autophagy and suppresses migration involving PI3K/Akt/mTOR and MAPK signalling pathway in human glioma cells
por: Luo, Ming, et al.
Publicado: (2016)

ABBV-744 induces autophagy in gastric cancer cells by regulating PI3K/AKT/mTOR/p70S6k and MAPK signaling pathways
por: Wang, Kun, et al.
Publicado: (2023)

Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways
por: Lu, Rui, et al.
Publicado: (2023)

Autophagy of macrophages is regulated by PI3k/Akt/mTOR signalling in the development of diabetic encephalopathy
por: Wang, Beiyun, et al.
Publicado: (2018)

Phosphorylation of zinc channel ZIP7 drives MAPK, PI3K and mTOR growth and proliferation signalling
por: Nimmanon, T., et al.
Publicado: (2017)

Chrysin Induces Apoptosis via the MAPK Pathway and Regulates ERK/mTOR-Mediated Autophagy in MC-3 Cells
por: Jung, Gi-Hwan, et al.
Publicado: (2022)

Autophagy Inhibits Inflammation via Down-Regulation of p38 MAPK/mTOR Signaling Cascade in Endothelial Cells
por: Zhou, Ling, et al.
Publicado: (2023)

Emergence of nasal chondrosarcoma in a dog with nasal polyposis
por: Sumner, Judd A., et al.
Publicado: (2018)

Autophagy termination and lysosome reformation regulated by mTOR
por: Yu, Li, et al.
Publicado: (2010)

mTOR's role in ageing: protein synthesis or autophagy?
por: Hands, Sarah L., et al.
Publicado: (2009)

mTOR, AMBRA1, and autophagy: An intricate relationship
por: Nazio, Francesca, et al.
Publicado: (2013)

Disruption of mTOR and MAPK pathways correlates with severity in idiopathic autism
por: Rosina, Eleonora, et al.
Publicado: (2019)

Pretreatment of Huoxue Jiedu Formula Ameliorates Myocardial Ischaemia/Reperfusion Injury by Decreasing Autophagy via Activation of the PI3K/AKT/mTOR Pathway
por: Long, Linzi, et al.
Publicado: (2021)

Mechanism of action of glucocorticoids in nasal polyposis
por: Fernandes, Atílio Maximino, et al.
Publicado: (2015)

The Effect of Bevacizumab and Propranolol on Nasal Polyposis
por: Olgun, Yuksel, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dro4ol1mj2p0qh6ui0j5c7if1l