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Does topical application of tranexamic acid reduce intraoperative bleeding in sinus surgery during general anesthesia?()

INTRODUCTION: Tranexamic acid is a hemostatic agent, which inhibits fibrin degradation, which may be beneficial in controlling bleeding during surgery. OBJECTIVES: The purpose of this study was to provide a meta-analysis and review of the effects of tranexamic acid on hemorrhage and surgical fields...

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Detalles Bibliográficos
Autores principales: Kang, Haram, Hwang, Se Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422563/
https://www.ncbi.nlm.nih.gov/pubmed/31653606
http://dx.doi.org/10.1016/j.bjorl.2019.08.006
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author Kang, Haram
Hwang, Se Hwan
author_facet Kang, Haram
Hwang, Se Hwan
author_sort Kang, Haram
collection PubMed
description INTRODUCTION: Tranexamic acid is a hemostatic agent, which inhibits fibrin degradation, which may be beneficial in controlling bleeding during surgery. OBJECTIVES: The purpose of this study was to provide a meta-analysis and review of the effects of tranexamic acid on hemorrhage and surgical fields and side effects on patients during endoscopic sinus surgery. METHODS: Two authors independently searched six databases (Medline, Scopus, Embase, Web of Science, Google Scholar and Cochrane library) from the start of article collection until July 2018. Postoperative complications such as intraoperative bleeding, operative time, hypotension, nausea, vomiting, and coagulation profile were included in the analysis of tranexamic acid (Treatment Group) and placebo (Control Group) during the operation. RESULTS: The amount of blood loss during surgery was statistically lower in the treatment group compared to the placebo group, and the surgical field quality was statistically higher in the treatment group than in the placebo group. On the other hand, there was no significant difference in operation time, hemodynamics, or coagulation profile between groups. In addition, tranexamic acid had no significant effect on vomiting and thrombosis compared to the Control Group. CONCLUSION: This meta-analysis has shown that topical administration of tranexamic acid can reduce the amount of bleeding during surgery and improve the overall quality of the surgery. Hemodynamic instability during surgery, vomiting after surgery, or abnormal clotting profile were not reported. Additional studies are needed to confirm the results of this study because there are fewer studies.
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spelling pubmed-94225632022-08-31 Does topical application of tranexamic acid reduce intraoperative bleeding in sinus surgery during general anesthesia?() Kang, Haram Hwang, Se Hwan Braz J Otorhinolaryngol Review Article INTRODUCTION: Tranexamic acid is a hemostatic agent, which inhibits fibrin degradation, which may be beneficial in controlling bleeding during surgery. OBJECTIVES: The purpose of this study was to provide a meta-analysis and review of the effects of tranexamic acid on hemorrhage and surgical fields and side effects on patients during endoscopic sinus surgery. METHODS: Two authors independently searched six databases (Medline, Scopus, Embase, Web of Science, Google Scholar and Cochrane library) from the start of article collection until July 2018. Postoperative complications such as intraoperative bleeding, operative time, hypotension, nausea, vomiting, and coagulation profile were included in the analysis of tranexamic acid (Treatment Group) and placebo (Control Group) during the operation. RESULTS: The amount of blood loss during surgery was statistically lower in the treatment group compared to the placebo group, and the surgical field quality was statistically higher in the treatment group than in the placebo group. On the other hand, there was no significant difference in operation time, hemodynamics, or coagulation profile between groups. In addition, tranexamic acid had no significant effect on vomiting and thrombosis compared to the Control Group. CONCLUSION: This meta-analysis has shown that topical administration of tranexamic acid can reduce the amount of bleeding during surgery and improve the overall quality of the surgery. Hemodynamic instability during surgery, vomiting after surgery, or abnormal clotting profile were not reported. Additional studies are needed to confirm the results of this study because there are fewer studies. Elsevier 2019-10-03 /pmc/articles/PMC9422563/ /pubmed/31653606 http://dx.doi.org/10.1016/j.bjorl.2019.08.006 Text en © 2019 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Kang, Haram
Hwang, Se Hwan
Does topical application of tranexamic acid reduce intraoperative bleeding in sinus surgery during general anesthesia?()
title Does topical application of tranexamic acid reduce intraoperative bleeding in sinus surgery during general anesthesia?()
title_full Does topical application of tranexamic acid reduce intraoperative bleeding in sinus surgery during general anesthesia?()
title_fullStr Does topical application of tranexamic acid reduce intraoperative bleeding in sinus surgery during general anesthesia?()
title_full_unstemmed Does topical application of tranexamic acid reduce intraoperative bleeding in sinus surgery during general anesthesia?()
title_short Does topical application of tranexamic acid reduce intraoperative bleeding in sinus surgery during general anesthesia?()
title_sort does topical application of tranexamic acid reduce intraoperative bleeding in sinus surgery during general anesthesia?()
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422563/
https://www.ncbi.nlm.nih.gov/pubmed/31653606
http://dx.doi.org/10.1016/j.bjorl.2019.08.006
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