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Prognostic value of pre-operative peripheral inflammation markers in patients with squamous cell carcinoma of the external auditory canal
INTRODUCTION: Squamous cell carcinoma of the external auditory canal is a rare entity. Previous studies have suggested predictors for tumor recurrence. However, most of the prognostic factors were from the clinicopathological aspect. OBJECTIVE: This study aims to analyze the correlation between pre-...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422596/ https://www.ncbi.nlm.nih.gov/pubmed/32624372 http://dx.doi.org/10.1016/j.bjorl.2020.05.018 |
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author | Li, Feitian Shi, Xunbei Dai, Chunfu |
author_facet | Li, Feitian Shi, Xunbei Dai, Chunfu |
author_sort | Li, Feitian |
collection | PubMed |
description | INTRODUCTION: Squamous cell carcinoma of the external auditory canal is a rare entity. Previous studies have suggested predictors for tumor recurrence. However, most of the prognostic factors were from the clinicopathological aspect. OBJECTIVE: This study aims to analyze the correlation between pre-operative peripheral inflammation markers and survival outcomes, in order to identify prognostic biomarkers for patients with squamous cell carcinoma of the external auditory canal. METHODS: We retrospectively analyzed patients diagnosed with squamous cell carcinoma of the external auditory canal who underwent surgery at our institute. The pre-operative circulating inflammatory markers, such as the neutrophil, lymphocyte, platelet, and monocyte counts were measured and their ratios including neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and lymphocyte-to-monocyte ratio were calculated. The prognostic value of the measured hematologic parameters in relation to the survival outcomes was also evaluated. RESULTS: A total of 83 patients were included, of which 26 patients showed tumor recurrence and 57 without recurrence. Neutrophil counts and neutrophil-to-lymphocyte ratio were closely connected with tumor stage. In the patients with recurrence, neutrophil counts, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were elevated (p < 0.0001, p < 0.0001 and p = 0.001), while lymphocyte counts and lymphocyte-to-monocyte ratio were decreased (p = 0.013 and p = 0.016, respectively). The receiver operating curve analysis indicated that pre-operative neutrophil-to-lymphocyte ratio is a potential prognostic marker for recurrence of squamous cell carcinoma of the external auditory canal (area under curve = 0.816), and the cut-off points was 2.325. CONCLUSIONS: Pre-operative neutrophil and lymphocyte counts, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte are significantly correlated with tumor recurrence in patients with external auditory canal squamous cell carcinoma. Furthermore, neutrophil-to-lymphocyte ratio may be unfavorable prognostic factors of this disease. |
format | Online Article Text |
id | pubmed-9422596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94225962022-08-31 Prognostic value of pre-operative peripheral inflammation markers in patients with squamous cell carcinoma of the external auditory canal Li, Feitian Shi, Xunbei Dai, Chunfu Braz J Otorhinolaryngol Original Article INTRODUCTION: Squamous cell carcinoma of the external auditory canal is a rare entity. Previous studies have suggested predictors for tumor recurrence. However, most of the prognostic factors were from the clinicopathological aspect. OBJECTIVE: This study aims to analyze the correlation between pre-operative peripheral inflammation markers and survival outcomes, in order to identify prognostic biomarkers for patients with squamous cell carcinoma of the external auditory canal. METHODS: We retrospectively analyzed patients diagnosed with squamous cell carcinoma of the external auditory canal who underwent surgery at our institute. The pre-operative circulating inflammatory markers, such as the neutrophil, lymphocyte, platelet, and monocyte counts were measured and their ratios including neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and lymphocyte-to-monocyte ratio were calculated. The prognostic value of the measured hematologic parameters in relation to the survival outcomes was also evaluated. RESULTS: A total of 83 patients were included, of which 26 patients showed tumor recurrence and 57 without recurrence. Neutrophil counts and neutrophil-to-lymphocyte ratio were closely connected with tumor stage. In the patients with recurrence, neutrophil counts, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were elevated (p < 0.0001, p < 0.0001 and p = 0.001), while lymphocyte counts and lymphocyte-to-monocyte ratio were decreased (p = 0.013 and p = 0.016, respectively). The receiver operating curve analysis indicated that pre-operative neutrophil-to-lymphocyte ratio is a potential prognostic marker for recurrence of squamous cell carcinoma of the external auditory canal (area under curve = 0.816), and the cut-off points was 2.325. CONCLUSIONS: Pre-operative neutrophil and lymphocyte counts, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte are significantly correlated with tumor recurrence in patients with external auditory canal squamous cell carcinoma. Furthermore, neutrophil-to-lymphocyte ratio may be unfavorable prognostic factors of this disease. Elsevier 2020-06-24 /pmc/articles/PMC9422596/ /pubmed/32624372 http://dx.doi.org/10.1016/j.bjorl.2020.05.018 Text en © 2020 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Article Li, Feitian Shi, Xunbei Dai, Chunfu Prognostic value of pre-operative peripheral inflammation markers in patients with squamous cell carcinoma of the external auditory canal |
title | Prognostic value of pre-operative peripheral inflammation markers in patients with squamous cell carcinoma of the external auditory canal |
title_full | Prognostic value of pre-operative peripheral inflammation markers in patients with squamous cell carcinoma of the external auditory canal |
title_fullStr | Prognostic value of pre-operative peripheral inflammation markers in patients with squamous cell carcinoma of the external auditory canal |
title_full_unstemmed | Prognostic value of pre-operative peripheral inflammation markers in patients with squamous cell carcinoma of the external auditory canal |
title_short | Prognostic value of pre-operative peripheral inflammation markers in patients with squamous cell carcinoma of the external auditory canal |
title_sort | prognostic value of pre-operative peripheral inflammation markers in patients with squamous cell carcinoma of the external auditory canal |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422596/ https://www.ncbi.nlm.nih.gov/pubmed/32624372 http://dx.doi.org/10.1016/j.bjorl.2020.05.018 |
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