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Cohort profile: population-based cohorts of patients with colorectal cancer and of their relatives in Geneva, Switzerland
PURPOSE: Colorectal cancer (CRC) is the third leading cause of cancer death worldwide. Variability between patients in prognosis and treatment response is partially explained by traditional clinicopathological factors. We established a large population-based cohort of patients with CRC and their fir...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422819/ https://www.ncbi.nlm.nih.gov/pubmed/36008070 http://dx.doi.org/10.1136/bmjopen-2022-063914 |
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author | Benhamou, Simone Fournier, Evelyne Puppa, Giacomo McKee, Thomas Ris, Frédéric Rubbia-Brandt, Laura Viassolo, Valeria Zilli, Thomas Zlobec, Inti Chappuis, Pierre Olivier Rapiti, Elisabetta |
author_facet | Benhamou, Simone Fournier, Evelyne Puppa, Giacomo McKee, Thomas Ris, Frédéric Rubbia-Brandt, Laura Viassolo, Valeria Zilli, Thomas Zlobec, Inti Chappuis, Pierre Olivier Rapiti, Elisabetta |
author_sort | Benhamou, Simone |
collection | PubMed |
description | PURPOSE: Colorectal cancer (CRC) is the third leading cause of cancer death worldwide. Variability between patients in prognosis and treatment response is partially explained by traditional clinicopathological factors. We established a large population-based cohort of patients with CRC and their first-degree and second-degree relatives registered in the Canton of Geneva, to evaluate the role of family history and tumour biomarkers on patient outcomes. PARTICIPANTS: The cohort includes all patients with CRC diagnosed between 1985 and 2013. Detailed information on patient and tumour characteristics, treatment and outcomes were extracted from the Geneva Cancer Registry database, completed by medical records review and linkage with administrative and oncogenetics databases. Next-generation tissue microarrays were constructed from tissue samples of the primary tumour. A prospective follow-up of the cohort is realised annually to collect data on outcomes. First-degree and second-degree relatives of patients are identified through linkage with the Cantonal Population Office database and information about cancer among relatives is retrieved from the Geneva Cancer Registry database. The cohort of relatives is updated annually. FINDINGS TO DATE: The cohort includes 5499 patients (4244 patients with colon cancer and 1255 patients with rectal cancer). The great majority of patients were diagnosed because of occurrence of symptoms and almost half of the cases were diagnosed with an advanced disease. At the end of 2019, 337 local recurrences, 1143 distant recurrences and 4035 deaths were reported. At the same date, the cohort of first-degree relatives included 344 fathers, 538 mothers, 3485 children and 375 siblings. Among them, we identified 28 fathers, 31 mothers, 18 siblings and 53 children who had a diagnosis of CRC. FUTURE PLANS: The cohort will be used for long-term studies of CRC epidemiology with focus on clinicopathological factors and molecular markers. These data will be correlated with the most up-to-date follow-up data. |
format | Online Article Text |
id | pubmed-9422819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-94228192022-09-12 Cohort profile: population-based cohorts of patients with colorectal cancer and of their relatives in Geneva, Switzerland Benhamou, Simone Fournier, Evelyne Puppa, Giacomo McKee, Thomas Ris, Frédéric Rubbia-Brandt, Laura Viassolo, Valeria Zilli, Thomas Zlobec, Inti Chappuis, Pierre Olivier Rapiti, Elisabetta BMJ Open Epidemiology PURPOSE: Colorectal cancer (CRC) is the third leading cause of cancer death worldwide. Variability between patients in prognosis and treatment response is partially explained by traditional clinicopathological factors. We established a large population-based cohort of patients with CRC and their first-degree and second-degree relatives registered in the Canton of Geneva, to evaluate the role of family history and tumour biomarkers on patient outcomes. PARTICIPANTS: The cohort includes all patients with CRC diagnosed between 1985 and 2013. Detailed information on patient and tumour characteristics, treatment and outcomes were extracted from the Geneva Cancer Registry database, completed by medical records review and linkage with administrative and oncogenetics databases. Next-generation tissue microarrays were constructed from tissue samples of the primary tumour. A prospective follow-up of the cohort is realised annually to collect data on outcomes. First-degree and second-degree relatives of patients are identified through linkage with the Cantonal Population Office database and information about cancer among relatives is retrieved from the Geneva Cancer Registry database. The cohort of relatives is updated annually. FINDINGS TO DATE: The cohort includes 5499 patients (4244 patients with colon cancer and 1255 patients with rectal cancer). The great majority of patients were diagnosed because of occurrence of symptoms and almost half of the cases were diagnosed with an advanced disease. At the end of 2019, 337 local recurrences, 1143 distant recurrences and 4035 deaths were reported. At the same date, the cohort of first-degree relatives included 344 fathers, 538 mothers, 3485 children and 375 siblings. Among them, we identified 28 fathers, 31 mothers, 18 siblings and 53 children who had a diagnosis of CRC. FUTURE PLANS: The cohort will be used for long-term studies of CRC epidemiology with focus on clinicopathological factors and molecular markers. These data will be correlated with the most up-to-date follow-up data. BMJ Publishing Group 2022-08-25 /pmc/articles/PMC9422819/ /pubmed/36008070 http://dx.doi.org/10.1136/bmjopen-2022-063914 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Epidemiology Benhamou, Simone Fournier, Evelyne Puppa, Giacomo McKee, Thomas Ris, Frédéric Rubbia-Brandt, Laura Viassolo, Valeria Zilli, Thomas Zlobec, Inti Chappuis, Pierre Olivier Rapiti, Elisabetta Cohort profile: population-based cohorts of patients with colorectal cancer and of their relatives in Geneva, Switzerland |
title | Cohort profile: population-based cohorts of patients with colorectal cancer and of their relatives in Geneva, Switzerland |
title_full | Cohort profile: population-based cohorts of patients with colorectal cancer and of their relatives in Geneva, Switzerland |
title_fullStr | Cohort profile: population-based cohorts of patients with colorectal cancer and of their relatives in Geneva, Switzerland |
title_full_unstemmed | Cohort profile: population-based cohorts of patients with colorectal cancer and of their relatives in Geneva, Switzerland |
title_short | Cohort profile: population-based cohorts of patients with colorectal cancer and of their relatives in Geneva, Switzerland |
title_sort | cohort profile: population-based cohorts of patients with colorectal cancer and of their relatives in geneva, switzerland |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422819/ https://www.ncbi.nlm.nih.gov/pubmed/36008070 http://dx.doi.org/10.1136/bmjopen-2022-063914 |
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