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Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma

The aim of this study was to investigate the factors related to large-volume central cervical lymph node metastasis (LNM) in papillary thyroid carcinoma. A retrospective study of 340 patients with 642 papillary thyroid carcinoma nodules who underwent thyroidectomy in Peking Union Medical College Hos...

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Autores principales: Tan, Li, Ji, Jiaqi, Sharen, Gaowa, Liu, Yuewu, Lv, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423095/
https://www.ncbi.nlm.nih.gov/pubmed/36046785
http://dx.doi.org/10.3389/fendo.2022.935559
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author Tan, Li
Ji, Jiaqi
Sharen, Gaowa
Liu, Yuewu
Lv, Ke
author_facet Tan, Li
Ji, Jiaqi
Sharen, Gaowa
Liu, Yuewu
Lv, Ke
author_sort Tan, Li
collection PubMed
description The aim of this study was to investigate the factors related to large-volume central cervical lymph node metastasis (LNM) in papillary thyroid carcinoma. A retrospective study of 340 patients with 642 papillary thyroid carcinoma nodules who underwent thyroidectomy in Peking Union Medical College Hospital between 2011 and 2015 was conducted. These nodules were divided into two groups by the number of central cervical lymph node metastases: large‐volume central cervical LNM (>5 metastatic lymph nodes, n = 129) and no central cervical LNM (n = 211). We evaluated the correlations between gender, age, chronic lymphocytic thyroiditis, thyroid ultrasonographic features, and large‐volume central cervical LNM. We found that younger age (≤40 years) (OR = 3.796, 95% CI = 2.842, 5.070), male gender (OR = 4.005, 95% CI = 2.858, 5.61), and ultrasonographic features such as tumor macroaxis size (OR = 2.985, 95% CI = 1.581, 5.633), tumor located in the isthmus (OR = 7.578, 95% CI = 4.863, 11.810), ill-defined margin (OR = 3.008, 95% CI = 1.986, 4.556), microcalcification (OR = 2.155, 95% CI = 1.585, 2.929), and abnormal cervical lymph nodes (OR = 13.753, 95% CI = 9.278, 20.385) were independent risk factors for large-volume central cervical LNM in papillary thyroid carcinoma, while chronic lymphocytic thyroiditis (OR = 0.248, 95% CI = 0.172, 0.358) was a protective factor. Younger age (≤40 years), male sex, and ultrasonographic features such as tumor macroaxis size, tumor located in the isthmus, ill-defined margin, microcalcification, and abnormal cervical lymph nodes were independent risk factors for large-volume central cervical LNM in papillary thyroid carcinoma, while chronic lymphocytic thyroiditis can be considered a protective factor. Our results provide a reference for adjusting clinical treatment approaches.
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spelling pubmed-94230952022-08-30 Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma Tan, Li Ji, Jiaqi Sharen, Gaowa Liu, Yuewu Lv, Ke Front Endocrinol (Lausanne) Endocrinology The aim of this study was to investigate the factors related to large-volume central cervical lymph node metastasis (LNM) in papillary thyroid carcinoma. A retrospective study of 340 patients with 642 papillary thyroid carcinoma nodules who underwent thyroidectomy in Peking Union Medical College Hospital between 2011 and 2015 was conducted. These nodules were divided into two groups by the number of central cervical lymph node metastases: large‐volume central cervical LNM (>5 metastatic lymph nodes, n = 129) and no central cervical LNM (n = 211). We evaluated the correlations between gender, age, chronic lymphocytic thyroiditis, thyroid ultrasonographic features, and large‐volume central cervical LNM. We found that younger age (≤40 years) (OR = 3.796, 95% CI = 2.842, 5.070), male gender (OR = 4.005, 95% CI = 2.858, 5.61), and ultrasonographic features such as tumor macroaxis size (OR = 2.985, 95% CI = 1.581, 5.633), tumor located in the isthmus (OR = 7.578, 95% CI = 4.863, 11.810), ill-defined margin (OR = 3.008, 95% CI = 1.986, 4.556), microcalcification (OR = 2.155, 95% CI = 1.585, 2.929), and abnormal cervical lymph nodes (OR = 13.753, 95% CI = 9.278, 20.385) were independent risk factors for large-volume central cervical LNM in papillary thyroid carcinoma, while chronic lymphocytic thyroiditis (OR = 0.248, 95% CI = 0.172, 0.358) was a protective factor. Younger age (≤40 years), male sex, and ultrasonographic features such as tumor macroaxis size, tumor located in the isthmus, ill-defined margin, microcalcification, and abnormal cervical lymph nodes were independent risk factors for large-volume central cervical LNM in papillary thyroid carcinoma, while chronic lymphocytic thyroiditis can be considered a protective factor. Our results provide a reference for adjusting clinical treatment approaches. Frontiers Media S.A. 2022-08-15 /pmc/articles/PMC9423095/ /pubmed/36046785 http://dx.doi.org/10.3389/fendo.2022.935559 Text en Copyright © 2022 Tan, Ji, Sharen, Liu and Lv https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Tan, Li
Ji, Jiaqi
Sharen, Gaowa
Liu, Yuewu
Lv, Ke
Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma
title Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma
title_full Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma
title_fullStr Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma
title_full_unstemmed Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma
title_short Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma
title_sort related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423095/
https://www.ncbi.nlm.nih.gov/pubmed/36046785
http://dx.doi.org/10.3389/fendo.2022.935559
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