Huntington’s disease phenotypes are improved via mTORC1 modulation by small molecule therapy

Huntington’s Disease (HD) is a dominantly inherited neurodegenerative disease for which the major causes of mortality are neurodegeneration-associated aspiration pneumonia followed by cardiac failure. mTORC1 pathway perturbations are present in HD models and human tissues. Amelioration of mTORC1 def...

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Detalles Bibliográficos
Autores principales: St-Cyr, Sophie, Child, Daniel D., Giaime, Emilie, Smith, Alicia R., Pascua, Christine J., Hahm, Seung, Saiah, Eddine, Davidson, Beverly L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423655/
https://www.ncbi.nlm.nih.gov/pubmed/36037192
http://dx.doi.org/10.1371/journal.pone.0273710

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