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More comprehensive proprioceptive stimulation of the hand amplifies its cortical processing

Corticokinematic coherence (CKC) quantifies the phase coupling between limb kinematics and cortical neurophysiological signals reflecting proprioceptive feedback to the primary sensorimotor (SM1) cortex. We studied whether the CKC strength or cortical source location differs between proprioceptive s...

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Autores principales: Hakonen, Maria, Nurmi, Timo, Vallinoja, Jaakko, Jaatela, Julia, Piitulainen, Harri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423773/
https://www.ncbi.nlm.nih.gov/pubmed/35858122
http://dx.doi.org/10.1152/jn.00485.2021
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author Hakonen, Maria
Nurmi, Timo
Vallinoja, Jaakko
Jaatela, Julia
Piitulainen, Harri
author_facet Hakonen, Maria
Nurmi, Timo
Vallinoja, Jaakko
Jaatela, Julia
Piitulainen, Harri
author_sort Hakonen, Maria
collection PubMed
description Corticokinematic coherence (CKC) quantifies the phase coupling between limb kinematics and cortical neurophysiological signals reflecting proprioceptive feedback to the primary sensorimotor (SM1) cortex. We studied whether the CKC strength or cortical source location differs between proprioceptive stimulation (i.e., actuator-evoked movements) of right-hand digits (index, middle, ring, and little). Twenty-one volunteers participated in magnetoencephalography measurements during which three conditions were tested: 1) simultaneous stimulation of all four fingers at the same frequency, 2) stimulation of each finger separately at the same frequency, and 3) simultaneous stimulation of the fingers at finger-specific frequencies. CKC was computed between MEG responses and accelerations of the fingers recorded with three-axis accelerometers. CKC was stronger (P < 0.003) for the simultaneous (0.52 ± 0.02) than separate (0.45 ± 0.02) stimulation at the same frequency. Furthermore, CKC was weaker (P < 0.03) for the simultaneous stimulation at the finger-specific frequencies (0.38 ± 0.02) than for the separate stimulation. CKC source locations of the fingers were concentrated in the hand region of the SM1 cortex and did not follow consistent finger-specific somatotopic order. Our results indicate that proprioceptive afference from the fingers is processed in partly overlapping cortical neuronal circuits, which was demonstrated by the modulation of the finger-specific CKC strengths due to proprioceptive afference arising from simultaneous stimulation of the other fingers of the same hand as well as overlapping cortical source locations. Finally, comprehensive simultaneous proprioceptive stimulation of the hand would optimize functional cortical mapping to pinpoint the hand region, e.g., prior brain surgery. NEW & NOTEWORTHY Corticokinematic coherence (CKC) can be used to study cortical proprioceptive processing and localize proprioceptive hand representation. Our results indicate that proprioceptive stimulation delivered simultaneously at the same frequency to fingers (D2–D4) maximizes CKC strength allowing robust and fast localization of the human hand region in the sensorimotor cortex using MEG.
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spelling pubmed-94237732022-09-06 More comprehensive proprioceptive stimulation of the hand amplifies its cortical processing Hakonen, Maria Nurmi, Timo Vallinoja, Jaakko Jaatela, Julia Piitulainen, Harri J Neurophysiol Research Article Corticokinematic coherence (CKC) quantifies the phase coupling between limb kinematics and cortical neurophysiological signals reflecting proprioceptive feedback to the primary sensorimotor (SM1) cortex. We studied whether the CKC strength or cortical source location differs between proprioceptive stimulation (i.e., actuator-evoked movements) of right-hand digits (index, middle, ring, and little). Twenty-one volunteers participated in magnetoencephalography measurements during which three conditions were tested: 1) simultaneous stimulation of all four fingers at the same frequency, 2) stimulation of each finger separately at the same frequency, and 3) simultaneous stimulation of the fingers at finger-specific frequencies. CKC was computed between MEG responses and accelerations of the fingers recorded with three-axis accelerometers. CKC was stronger (P < 0.003) for the simultaneous (0.52 ± 0.02) than separate (0.45 ± 0.02) stimulation at the same frequency. Furthermore, CKC was weaker (P < 0.03) for the simultaneous stimulation at the finger-specific frequencies (0.38 ± 0.02) than for the separate stimulation. CKC source locations of the fingers were concentrated in the hand region of the SM1 cortex and did not follow consistent finger-specific somatotopic order. Our results indicate that proprioceptive afference from the fingers is processed in partly overlapping cortical neuronal circuits, which was demonstrated by the modulation of the finger-specific CKC strengths due to proprioceptive afference arising from simultaneous stimulation of the other fingers of the same hand as well as overlapping cortical source locations. Finally, comprehensive simultaneous proprioceptive stimulation of the hand would optimize functional cortical mapping to pinpoint the hand region, e.g., prior brain surgery. NEW & NOTEWORTHY Corticokinematic coherence (CKC) can be used to study cortical proprioceptive processing and localize proprioceptive hand representation. Our results indicate that proprioceptive stimulation delivered simultaneously at the same frequency to fingers (D2–D4) maximizes CKC strength allowing robust and fast localization of the human hand region in the sensorimotor cortex using MEG. American Physiological Society 2022-09-01 2022-07-20 /pmc/articles/PMC9423773/ /pubmed/35858122 http://dx.doi.org/10.1152/jn.00485.2021 Text en Copyright © 2022 The Authors https://creativecommons.org/licenses/by/4.0/Licensed under Creative Commons Attribution CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/) . Published by the American Physiological Society.
spellingShingle Research Article
Hakonen, Maria
Nurmi, Timo
Vallinoja, Jaakko
Jaatela, Julia
Piitulainen, Harri
More comprehensive proprioceptive stimulation of the hand amplifies its cortical processing
title More comprehensive proprioceptive stimulation of the hand amplifies its cortical processing
title_full More comprehensive proprioceptive stimulation of the hand amplifies its cortical processing
title_fullStr More comprehensive proprioceptive stimulation of the hand amplifies its cortical processing
title_full_unstemmed More comprehensive proprioceptive stimulation of the hand amplifies its cortical processing
title_short More comprehensive proprioceptive stimulation of the hand amplifies its cortical processing
title_sort more comprehensive proprioceptive stimulation of the hand amplifies its cortical processing
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423773/
https://www.ncbi.nlm.nih.gov/pubmed/35858122
http://dx.doi.org/10.1152/jn.00485.2021
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