“A new case of myasthenia gravis following COVID-19 Vaccination”

BACKGROUND: Myasthenia gravis (MG) is an autoimmune disease of unknown etiology. Infections are known as a major cause of MG exacerbations. A few studies have shown an association between new onset MG and SARS-CoV-2 infection. CASE PRESENTATION: We have reported a case of new onset myasthenia gravis...

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Autores principales: Abna, Zohreh, Khanmoradi, Ziba, Abna, Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423877/
http://dx.doi.org/10.1016/j.nerep.2022.100128
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author Abna, Zohreh
Khanmoradi, Ziba
Abna, Zahra
author_facet Abna, Zohreh
Khanmoradi, Ziba
Abna, Zahra
author_sort Abna, Zohreh
collection PubMed
description BACKGROUND: Myasthenia gravis (MG) is an autoimmune disease of unknown etiology. Infections are known as a major cause of MG exacerbations. A few studies have shown an association between new onset MG and SARS-CoV-2 infection. CASE PRESENTATION: We have reported a case of new onset myasthenia gravis in a 68-year-old man presented with bulbar symptoms a few days after receiving COVID-19 vaccine (Sinopharm vaccine). The disease was confirmed by high titer of antibody against acetylcholine receptor and electrophysiological examinations. CONCLUSION: Among the adverse effects reported with the COVID-19 vaccine, new onset myasthenia gravis is very rare. The underlying mechanism is unknown but the immune response after vaccination and molecular mimicry theory has been proposed.
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spelling pubmed-94238772022-08-30 “A new case of myasthenia gravis following COVID-19 Vaccination” Abna, Zohreh Khanmoradi, Ziba Abna, Zahra Neuroimmunology Reports Article BACKGROUND: Myasthenia gravis (MG) is an autoimmune disease of unknown etiology. Infections are known as a major cause of MG exacerbations. A few studies have shown an association between new onset MG and SARS-CoV-2 infection. CASE PRESENTATION: We have reported a case of new onset myasthenia gravis in a 68-year-old man presented with bulbar symptoms a few days after receiving COVID-19 vaccine (Sinopharm vaccine). The disease was confirmed by high titer of antibody against acetylcholine receptor and electrophysiological examinations. CONCLUSION: Among the adverse effects reported with the COVID-19 vaccine, new onset myasthenia gravis is very rare. The underlying mechanism is unknown but the immune response after vaccination and molecular mimicry theory has been proposed. The Authors. Published by Elsevier B.V. 2022 2022-08-30 /pmc/articles/PMC9423877/ http://dx.doi.org/10.1016/j.nerep.2022.100128 Text en © 2022 The Authors. Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Abna, Zohreh
Khanmoradi, Ziba
Abna, Zahra
“A new case of myasthenia gravis following COVID-19 Vaccination”
title “A new case of myasthenia gravis following COVID-19 Vaccination”
title_full “A new case of myasthenia gravis following COVID-19 Vaccination”
title_fullStr “A new case of myasthenia gravis following COVID-19 Vaccination”
title_full_unstemmed “A new case of myasthenia gravis following COVID-19 Vaccination”
title_short “A new case of myasthenia gravis following COVID-19 Vaccination”
title_sort “a new case of myasthenia gravis following covid-19 vaccination”
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423877/
http://dx.doi.org/10.1016/j.nerep.2022.100128
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