Fatal Fungicide-Associated Triazole-Resistant Aspergillus fumigatus Infection, Pennsylvania, USA

We report a fatal infection in a 65-year-old immunocompromised male patient caused by pan-triazole–resistant Aspergillus fumigatus containing a TR(34)/L98H genetic mutation linked to agricultural fungicide use. Clinical and environmental surveillance of triazole-resistant A. fumigatus is needed in t...

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Detalles Bibliográficos
Autores principales: Bradley, Kennedy, Le-Mahajan, Audrey, Morris, Beth, Peritz, Tiina, Chiller, Tom, Forsberg, Kaitlin, Nunnally, Natalie S., Lockhart, Shawn R., Gold, Jeremy A.W., Gould, Jane M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423893/
https://www.ncbi.nlm.nih.gov/pubmed/35997507
http://dx.doi.org/10.3201/eid2809.220517
Descripción
Sumario:We report a fatal infection in a 65-year-old immunocompromised male patient caused by pan-triazole–resistant Aspergillus fumigatus containing a TR(34)/L98H genetic mutation linked to agricultural fungicide use. Clinical and environmental surveillance of triazole-resistant A. fumigatus is needed in the United States to prevent spread and guide healthcare and agricultural practices.

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