Fatal Fungicide-Associated Triazole-Resistant Aspergillus fumigatus Infection, Pennsylvania, USA

We report a fatal infection in a 65-year-old immunocompromised male patient caused by pan-triazole–resistant Aspergillus fumigatus containing a TR(34)/L98H genetic mutation linked to agricultural fungicide use. Clinical and environmental surveillance of triazole-resistant A. fumigatus is needed in t...

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Autores principales: Bradley, Kennedy, Le-Mahajan, Audrey, Morris, Beth, Peritz, Tiina, Chiller, Tom, Forsberg, Kaitlin, Nunnally, Natalie S., Lockhart, Shawn R., Gold, Jeremy A.W., Gould, Jane M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423893/
https://www.ncbi.nlm.nih.gov/pubmed/35997507
http://dx.doi.org/10.3201/eid2809.220517
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author Bradley, Kennedy
Le-Mahajan, Audrey
Morris, Beth
Peritz, Tiina
Chiller, Tom
Forsberg, Kaitlin
Nunnally, Natalie S.
Lockhart, Shawn R.
Gold, Jeremy A.W.
Gould, Jane M.
author_facet Bradley, Kennedy
Le-Mahajan, Audrey
Morris, Beth
Peritz, Tiina
Chiller, Tom
Forsberg, Kaitlin
Nunnally, Natalie S.
Lockhart, Shawn R.
Gold, Jeremy A.W.
Gould, Jane M.
author_sort Bradley, Kennedy
collection PubMed
description We report a fatal infection in a 65-year-old immunocompromised male patient caused by pan-triazole–resistant Aspergillus fumigatus containing a TR(34)/L98H genetic mutation linked to agricultural fungicide use. Clinical and environmental surveillance of triazole-resistant A. fumigatus is needed in the United States to prevent spread and guide healthcare and agricultural practices.
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spelling pubmed-94238932022-09-07 Fatal Fungicide-Associated Triazole-Resistant Aspergillus fumigatus Infection, Pennsylvania, USA Bradley, Kennedy Le-Mahajan, Audrey Morris, Beth Peritz, Tiina Chiller, Tom Forsberg, Kaitlin Nunnally, Natalie S. Lockhart, Shawn R. Gold, Jeremy A.W. Gould, Jane M. Emerg Infect Dis Research Letter We report a fatal infection in a 65-year-old immunocompromised male patient caused by pan-triazole–resistant Aspergillus fumigatus containing a TR(34)/L98H genetic mutation linked to agricultural fungicide use. Clinical and environmental surveillance of triazole-resistant A. fumigatus is needed in the United States to prevent spread and guide healthcare and agricultural practices. Centers for Disease Control and Prevention 2022-09 /pmc/articles/PMC9423893/ /pubmed/35997507 http://dx.doi.org/10.3201/eid2809.220517 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Bradley, Kennedy
Le-Mahajan, Audrey
Morris, Beth
Peritz, Tiina
Chiller, Tom
Forsberg, Kaitlin
Nunnally, Natalie S.
Lockhart, Shawn R.
Gold, Jeremy A.W.
Gould, Jane M.
Fatal Fungicide-Associated Triazole-Resistant Aspergillus fumigatus Infection, Pennsylvania, USA
title Fatal Fungicide-Associated Triazole-Resistant Aspergillus fumigatus Infection, Pennsylvania, USA
title_full Fatal Fungicide-Associated Triazole-Resistant Aspergillus fumigatus Infection, Pennsylvania, USA
title_fullStr Fatal Fungicide-Associated Triazole-Resistant Aspergillus fumigatus Infection, Pennsylvania, USA
title_full_unstemmed Fatal Fungicide-Associated Triazole-Resistant Aspergillus fumigatus Infection, Pennsylvania, USA
title_short Fatal Fungicide-Associated Triazole-Resistant Aspergillus fumigatus Infection, Pennsylvania, USA
title_sort fatal fungicide-associated triazole-resistant aspergillus fumigatus infection, pennsylvania, usa
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423893/
https://www.ncbi.nlm.nih.gov/pubmed/35997507
http://dx.doi.org/10.3201/eid2809.220517
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