Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person

We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identifie...

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Detalles Bibliográficos
Autores principales: Munnink, Bas B. Oude, Nijhuis, Roel H.T., Worp, Nathalie, Boter, Marjan, Weller, Babette, Verstrepen, Babs E., GeurtsvanKessel, Corine, Corsten, Maarten F., Russcher, Anne, Koopmans, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423911/
https://www.ncbi.nlm.nih.gov/pubmed/35925013
http://dx.doi.org/10.3201/eid2809.220875
Descripción
Sumario:We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein.

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