Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person

We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identifie...

Descripción completa

Detalles Bibliográficos
Autores principales: Munnink, Bas B. Oude, Nijhuis, Roel H.T., Worp, Nathalie, Boter, Marjan, Weller, Babette, Verstrepen, Babs E., GeurtsvanKessel, Corine, Corsten, Maarten F., Russcher, Anne, Koopmans, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423911/
https://www.ncbi.nlm.nih.gov/pubmed/35925013
http://dx.doi.org/10.3201/eid2809.220875
_version_ 1784778121156755456
author Munnink, Bas B. Oude
Nijhuis, Roel H.T.
Worp, Nathalie
Boter, Marjan
Weller, Babette
Verstrepen, Babs E.
GeurtsvanKessel, Corine
Corsten, Maarten F.
Russcher, Anne
Koopmans, Marion
author_facet Munnink, Bas B. Oude
Nijhuis, Roel H.T.
Worp, Nathalie
Boter, Marjan
Weller, Babette
Verstrepen, Babs E.
GeurtsvanKessel, Corine
Corsten, Maarten F.
Russcher, Anne
Koopmans, Marion
author_sort Munnink, Bas B. Oude
collection PubMed
description We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein.
format Online
Article
Text
id pubmed-9423911
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Centers for Disease Control and Prevention
record_format MEDLINE/PubMed
spelling pubmed-94239112022-09-07 Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person Munnink, Bas B. Oude Nijhuis, Roel H.T. Worp, Nathalie Boter, Marjan Weller, Babette Verstrepen, Babs E. GeurtsvanKessel, Corine Corsten, Maarten F. Russcher, Anne Koopmans, Marion Emerg Infect Dis Research Letter We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein. Centers for Disease Control and Prevention 2022-09 /pmc/articles/PMC9423911/ /pubmed/35925013 http://dx.doi.org/10.3201/eid2809.220875 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Munnink, Bas B. Oude
Nijhuis, Roel H.T.
Worp, Nathalie
Boter, Marjan
Weller, Babette
Verstrepen, Babs E.
GeurtsvanKessel, Corine
Corsten, Maarten F.
Russcher, Anne
Koopmans, Marion
Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person
title Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person
title_full Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person
title_fullStr Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person
title_full_unstemmed Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person
title_short Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person
title_sort highly divergent sars-cov-2 alpha variant in chronically infected immunocompromised person
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423911/
https://www.ncbi.nlm.nih.gov/pubmed/35925013
http://dx.doi.org/10.3201/eid2809.220875
work_keys_str_mv AT munninkbasboude highlydivergentsarscov2alphavariantinchronicallyinfectedimmunocompromisedperson
AT nijhuisroelht highlydivergentsarscov2alphavariantinchronicallyinfectedimmunocompromisedperson
AT worpnathalie highlydivergentsarscov2alphavariantinchronicallyinfectedimmunocompromisedperson
AT botermarjan highlydivergentsarscov2alphavariantinchronicallyinfectedimmunocompromisedperson
AT wellerbabette highlydivergentsarscov2alphavariantinchronicallyinfectedimmunocompromisedperson
AT verstrepenbabse highlydivergentsarscov2alphavariantinchronicallyinfectedimmunocompromisedperson
AT geurtsvankesselcorine highlydivergentsarscov2alphavariantinchronicallyinfectedimmunocompromisedperson
AT corstenmaartenf highlydivergentsarscov2alphavariantinchronicallyinfectedimmunocompromisedperson
AT russcheranne highlydivergentsarscov2alphavariantinchronicallyinfectedimmunocompromisedperson
AT koopmansmarion highlydivergentsarscov2alphavariantinchronicallyinfectedimmunocompromisedperson

Ejemplares similares